(22 nodes) (2014) RNA-seq analysis of equine conceptus transcripts during embryo fixation and capsule disappearance. network (Equus caballus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ITGA4	Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1033 aa)
	ITGB4	Integrin beta. (1805 aa)
	COL5A2	Collagen type V alpha 2 chain. (1499 aa)
	VTN	Vitronectin. (478 aa)
	SPP1	Secreted phosphoprotein 1. (313 aa)
	COL6A2	Collagen type VI alpha 2 chain. (1018 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (225 aa)
	COL4A1	Collagen type IV alpha 1 chain. (1669 aa)
	RELN	Reelin. (3460 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	CHAD	Chondroadherin. (359 aa)
	COL6A1	Collagen type VI alpha 1 chain. (1027 aa)
	VWF	Von Willebrand factor. (2813 aa)
	SGCA	Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1075 aa)
	ITGB5	Integrin beta; Belongs to the integrin beta chain family. (837 aa)
	COL4A2	Collagen type IV alpha 2 chain. (1867 aa)
	ITGA5	Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1248 aa)
	COL4A5	Collagen type IV alpha 5 chain. (1691 aa)
	COL6A3	Collagen type VI alpha 3 chain. (3166 aa)
	ITGA6	Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa)
	COL4A6	Collagen type IV alpha 6 chain. (1708 aa)
	COL4A3	Collagen type IV alpha 3 chain. (1761 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAV3	GAPDH	ENSECAP00000018124	ENSECAP00000019665	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Glyceraldehyde-3-phosphate dehydrogenase.	0.505
CAV3	ITGB4	ENSECAP00000018124	ENSECAP00000009107	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Integrin beta.	0.700
CAV3	ITGB5	ENSECAP00000018124	ENSECAP00000035882	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Integrin beta; Belongs to the integrin beta chain family.	0.700
CHAD	COL6A1	ENSECAP00000020582	ENSECAP00000024163	Chondroadherin.	Collagen type VI alpha 1 chain.	0.403
CHAD	ITGA4	ENSECAP00000020582	ENSECAP00000009001	Chondroadherin.	Integrin subunit alpha 4; Belongs to the integrin alpha chain family.	0.690
CHAD	ITGA6	ENSECAP00000020582	ENSECAP00000052108	Chondroadherin.	Integrin subunit alpha 6; Belongs to the integrin alpha chain family.	0.662
CHAD	ITGB4	ENSECAP00000020582	ENSECAP00000009107	Chondroadherin.	Integrin beta.	0.707
CHAD	ITGB5	ENSECAP00000020582	ENSECAP00000035882	Chondroadherin.	Integrin beta; Belongs to the integrin beta chain family.	0.680
CHAD	SGCA	ENSECAP00000020582	ENSECAP00000034085	Chondroadherin.	Integrin subunit alpha 3; Belongs to the integrin alpha chain family.	0.693
COL4A1	COL4A2	ENSECAP00000018554	ENSECAP00000042479	Collagen type IV alpha 1 chain.	Collagen type IV alpha 2 chain.	0.978
COL4A1	COL4A3	ENSECAP00000018554	ENSECAP00000054895	Collagen type IV alpha 1 chain.	Collagen type IV alpha 3 chain.	0.412
COL4A1	COL4A5	ENSECAP00000018554	ENSECAP00000049976	Collagen type IV alpha 1 chain.	Collagen type IV alpha 5 chain.	0.401
COL4A1	COL4A6	ENSECAP00000018554	ENSECAP00000054599	Collagen type IV alpha 1 chain.	Collagen type IV alpha 6 chain.	0.936
COL4A1	COL5A2	ENSECAP00000018554	ENSECAP00000009423	Collagen type IV alpha 1 chain.	Collagen type V alpha 2 chain.	0.532
COL4A1	COL6A1	ENSECAP00000018554	ENSECAP00000024163	Collagen type IV alpha 1 chain.	Collagen type VI alpha 1 chain.	0.483
COL4A1	COL6A2	ENSECAP00000018554	ENSECAP00000017260	Collagen type IV alpha 1 chain.	Collagen type VI alpha 2 chain.	0.519
COL4A1	COL6A3	ENSECAP00000018554	ENSECAP00000051752	Collagen type IV alpha 1 chain.	Collagen type VI alpha 3 chain.	0.475
COL4A1	ITGA4	ENSECAP00000018554	ENSECAP00000009001	Collagen type IV alpha 1 chain.	Integrin subunit alpha 4; Belongs to the integrin alpha chain family.	0.769
COL4A1	ITGA5	ENSECAP00000018554	ENSECAP00000048172	Collagen type IV alpha 1 chain.	Integrin subunit alpha 5; Belongs to the integrin alpha chain family.	0.470
COL4A1	ITGA6	ENSECAP00000018554	ENSECAP00000052108	Collagen type IV alpha 1 chain.	Integrin subunit alpha 6; Belongs to the integrin alpha chain family.	0.791