STRINGSTRING
TRAF3IP2 TRAF3IP2 PTPN2 PTPN2 HMOX1 HMOX1 SLC4A1 SLC4A1 ADAR ADAR TRIM10 TRIM10 F6XH74_HORSE F6XH74_HORSE CEBPG CEBPG F6S6S0_HORSE F6S6S0_HORSE GCNT4 GCNT4 BCL6 BCL6 TSPO2 TSPO2 NCAPG2 NCAPG2 SH2B3 SH2B3 FANCC FANCC HSPA9 HSPA9 HMGB1 HMGB1 PRDX1 PRDX1 SRF SRF NF1 NF1 MED1 MED1 JAK2 JAK2 AHSP AHSP ETV2 ETV2 GATA1 GATA1 PKNOX1 PKNOX1 C1H15orf41 C1H15orf41 ATP5IF1 ATP5IF1 AXL AXL HOXB6 HOXB6 LYAR LYAR KIT KIT ADD1 ADD1 EPAS1 EPAS1 G6PD G6PD PDE1B PDE1B HCLS1 HCLS1 ANXA1 ANXA1 PLA2G10 PLA2G10 IL6 IL6 IREB2 IREB2 BMP4 BMP4 CSF1 CSF1 ABCB10 ABCB10 FLVCR1 FLVCR1 SMAD5 SMAD5 TAL1 TAL1 GPI GPI DNASE2 DNASE2 ARID4A ARID4A BAP1 BAP1 JMJD6 JMJD6 CASP3 CASP3 MPIG6B MPIG6B EPB42 EPB42 BAK1 BAK1 MERTK MERTK TMEM14C TMEM14C KCNQ1 KCNQ1 GATA3 GATA3 SLC37A4 SLC37A4 CDK5RAP3 CDK5RAP3 LIPA LIPA ZBTB7A ZBTB7A SLC25A38 SLC25A38 UFL1 UFL1 ITPKB ITPKB ERCC2 ERCC2 KMT2E KMT2E RCOR1 RCOR1 KLF1 KLF1 CITED2 CITED2 STAT5B STAT5B FOXP3 FOXP3 ZFPM1 ZFPM1 MTHFD1 MTHFD1 SP3 SP3 ADGRF5 ADGRF5 EPO EPO HSCB HSCB RB1 RB1 KITLG KITLG NCSTN NCSTN SOD1 SOD1 LYN LYN JAK3 JAK3 L3MBTL3 L3MBTL3 MFHAS1 MFHAS1 IKZF1 IKZF1 DYRK3 DYRK3 XKR8 XKR8 ENSECAP00000050619 ENSECAP00000050619 PDE4B PDE4B ALAS2 ALAS2 DMTN DMTN BCL2L11 BCL2L11 MAEA MAEA RPS24 RPS24 UBA5 UBA5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRAF3IP2TRAF3 interacting protein 2. (578 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (388 aa)
HMOX1Heme oxygenase 1. (490 aa)
SLC4A1Anion exchange protein. (934 aa)
ADARAdenosine deaminase RNA specific. (1171 aa)
TRIM10Tripartite motif containing 10. (481 aa)
F6XH74_HORSEUncharacterized protein. (215 aa)
CEBPGCCAAT enhancer binding protein gamma. (215 aa)
F6S6S0_HORSEUncharacterized protein. (212 aa)
GCNT4Glucosaminyl (N-acetyl) transferase 4. (561 aa)
BCL6BCL6 transcription repressor. (699 aa)
TSPO2Translocator protein 2. (171 aa)
NCAPG2Non-SMC condensin II complex subunit G2. (1142 aa)
SH2B3SH2B adaptor protein 3. (561 aa)
FANCCFA complementation group C. (623 aa)
HSPA9Heat shock protein family A (Hsp70) member 9; Belongs to the heat shock protein 70 family. (679 aa)
HMGB1High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...] (215 aa)
PRDX1Peroxiredoxin 1. (199 aa)
SRFSerum response factor. (512 aa)
NF1Neurofibromin 1. (3024 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
JAK2Tyrosine-protein kinase. (1131 aa)
AHSPAlpha hemoglobin stabilizing protein. (102 aa)
ETV2ETS variant 2. (248 aa)
GATA1GATA binding protein 1. (486 aa)
PKNOX1PBX/knotted 1 homeobox 1. (436 aa)
C1H15orf41Chromosome 1 C15orf41 homolog. (304 aa)
ATP5IF1ATP synthase inhibitory factor subunit 1. (108 aa)
AXLAXL receptor tyrosine kinase. (887 aa)
HOXB6Homeobox B6. (224 aa)
LYARLy1 antibody reactive. (388 aa)
KITKIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1084 aa)
ADD1Adducin 1. (771 aa)
EPAS1Endothelial PAS domain protein 1. (910 aa)
G6PDGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (637 aa)
PDE1BNCK associated protein 1 like. (1182 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (498 aa)
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (346 aa)
PLA2G10Phospholipase A(2). (160 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (231 aa)
IREB2Iron responsive element binding protein 2; Belongs to the aconitase/IPM isomerase family. (964 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
CSF1Colony stimulating factor 1. (630 aa)
ABCB10ATP binding cassette subfamily B member 10. (728 aa)
FLVCR1Feline leukemia virus subgroup C cellular receptor 1. (555 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (331 aa)
GPIGlucose-6-phosphate isomerase; Belongs to the GPI family. (573 aa)
DNASE2Deoxyribonuclease 2, lysosomal. (353 aa)
ARID4AAT-rich interaction domain 4A. (1273 aa)
BAP1Ubiquitin carboxyl-terminal hydrolase. (726 aa)
JMJD6Jumonji domain containing 6, arginine demethylase and lysine hydroxylase. (414 aa)
CASP3Caspase-3-like protein; Belongs to the peptidase C14A family. (277 aa)
MPIG6BMegakaryocyte and platelet inhibitory receptor G6b. (218 aa)
EPB42Erythrocyte membrane protein band 4.2. (714 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
MERTKMER proto-oncogene, tyrosine kinase. (993 aa)
TMEM14CTransmembrane protein 14C. (115 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (778 aa)
GATA3GATA binding protein 3. (445 aa)
SLC37A4Solute carrier family 37 member 4. (451 aa)
CDK5RAP3CDK5 regulatory subunit associated protein 3. (532 aa)
LIPALipase; Belongs to the AB hydrolase superfamily. Lipase family. (432 aa)
ZBTB7AZinc finger and BTB domain containing 7A. (794 aa)
SLC25A38Mitochondrial glycine transporter; Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis. Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. (304 aa)
UFL1UFM1 specific ligase 1. (791 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (1008 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (769 aa)
KMT2ELysine methyltransferase 2E. (1857 aa)
RCOR1REST corepressor 1. (528 aa)
KLF1Kruppel like factor 1. (360 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (294 aa)
STAT5BSignal transducer and activator of transcription. (825 aa)
FOXP3Forkhead box P3. (452 aa)
ZFPM1Zinc finger protein, FOG family member 1. (986 aa)
MTHFD1Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. (941 aa)
SP3Sp3 transcription factor. (790 aa)
ADGRF5Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family. (1386 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (194 aa)
HSCBHscB mitochondrial iron-sulfur cluster cochaperone. (267 aa)
RB1RB transcriptional corepressor 1. (965 aa)
KITLGProcessed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity); Belongs to the SCF family. (303 aa)
NCSTNNicastrin. (709 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (171 aa)
LYNTyrosine-protein kinase. (533 aa)
JAK3Tyrosine-protein kinase. (1139 aa)
L3MBTL3L3MBTL histone methyl-lysine binding protein 3. (780 aa)
MFHAS1Malignant fibrous histiocytoma amplified sequence 1. (1046 aa)
IKZF1IKAROS family zinc finger 1. (529 aa)
DYRK3Dual specificity tyrosine phosphorylation regulated kinase 3. (587 aa)
XKR8XK-related protein. (553 aa)
ENSECAP00000050619Thioredoxin domain-containing protein. (199 aa)
PDE4BPhosphodiesterase. (736 aa)
ALAS25-aminolevulinate synthase. (587 aa)
DMTNDematin actin binding protein. (405 aa)
BCL2L11BCL2 like 11. (289 aa)
MAEAMacrophage erythroblast attacher. (434 aa)
RPS2440S ribosomal protein S24; Belongs to the eukaryotic ribosomal protein eS24 family. (132 aa)
UBA5Ubiquitin like modifier activating enzyme 5. (404 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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