(11 nodes) (2021) Interruption of Endolysosomal Trafficking After Focal Brain Ischemia. network (Leptonychotes weddellii)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (255 aa)
	CTSD	Cathepsin D; Belongs to the peptidase A1 family. (410 aa)
	ATG12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
	CAV2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	TFEB	Transcription factor EB. (329 aa)
	CTSB	Cathepsin B; Belongs to the peptidase C1 family. (339 aa)
	MAP1A	Microtubule-associated protein 1A. (3034 aa)
	AQP4	Aquaporin-4; Belongs to the MIP/aquaporin (TC 1.A.8) family. (301 aa)
	EEA1	Early endosome antigen 1. (1155 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AQP4	CAV1	A0A2U3YPU6	A0A2U3XCN0	Aquaporin-4; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.478
ATG12	ATG5	A0A2U3XZP0	A0A2U3Y6R5	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.999
ATG12	CAV1	A0A2U3XZP0	A0A2U3XCN0	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.561
ATG12	CTSD	A0A2U3XZP0	A0A2U3Z5S6	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Cathepsin D; Belongs to the peptidase A1 family.	0.647
ATG12	MAP1A	A0A2U3XZP0	A0A2U3XJT6	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Microtubule-associated protein 1A.	0.776
ATG12	TFEB	A0A2U3XZP0	A0A2U3XD63	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Transcription factor EB.	0.472
ATG5	ATG12	A0A2U3Y6R5	A0A2U3XZP0	Autophagy protein 5; Involved in autophagic vesicle formation.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.999
ATG5	CAV1	A0A2U3Y6R5	A0A2U3XCN0	Autophagy protein 5; Involved in autophagic vesicle formation.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.486
ATG5	CTSB	A0A2U3Y6R5	A0A2U3XDA4	Autophagy protein 5; Involved in autophagic vesicle formation.	Cathepsin B; Belongs to the peptidase C1 family.	0.557
ATG5	CTSD	A0A2U3Y6R5	A0A2U3Z5S6	Autophagy protein 5; Involved in autophagic vesicle formation.	Cathepsin D; Belongs to the peptidase A1 family.	0.593
ATG5	EEA1	A0A2U3Y6R5	A0A2U3XVP0	Autophagy protein 5; Involved in autophagic vesicle formation.	Early endosome antigen 1.	0.536
ATG5	MAP1A	A0A2U3Y6R5	A0A2U3XJT6	Autophagy protein 5; Involved in autophagic vesicle formation.	Microtubule-associated protein 1A.	0.762
ATG5	TFEB	A0A2U3Y6R5	A0A2U3XD63	Autophagy protein 5; Involved in autophagic vesicle formation.	Transcription factor EB.	0.637
CAV1	AQP4	A0A2U3XCN0	A0A2U3YPU6	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Aquaporin-4; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.478
CAV1	ATG12	A0A2U3XCN0	A0A2U3XZP0	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.561
CAV1	ATG5	A0A2U3XCN0	A0A2U3Y6R5	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.486
CAV1	CAV2	A0A2U3XCN0	A0A2U3XC92	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.999
CAV1	CAV3	A0A2U3XCN0	A0A2U3XYT3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.952
CAV1	EEA1	A0A2U3XCN0	A0A2U3XVP0	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Early endosome antigen 1.	0.646
CAV2	CAV1	A0A2U3XC92	A0A2U3XCN0	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.999