node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALB | DPP4 | ENSMFAP00000002887 | ENSMFAP00000029520 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. | 0.545 |
ALB | ENSMFAP00000020437 | ENSMFAP00000002887 | ENSMFAP00000020437 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | Aspartate aminotransferase. | 0.921 |
ALB | FGF21 | ENSMFAP00000002887 | ENSMFAP00000017555 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.497 |
ALB | GCG | ENSMFAP00000002887 | ENSMFAP00000041572 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | Glucagon. | 0.603 |
ALB | GLP1R | ENSMFAP00000002887 | ENSMFAP00000035347 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | Glucagon-like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. | 0.547 |
ALB | INS | ENSMFAP00000002887 | ENSMFAP00000009056 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.854 |
ALB | LEP | ENSMFAP00000002887 | ENSMFAP00000024992 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.586 |
ALB | PPARG | ENSMFAP00000002887 | ENSMFAP00000035941 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.471 |
DPP4 | ALB | ENSMFAP00000029520 | ENSMFAP00000002887 | Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | 0.545 |
DPP4 | GAST | ENSMFAP00000029520 | ENSMFAP00000018433 | Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. | Gastrin. | 0.555 |
DPP4 | GCG | ENSMFAP00000029520 | ENSMFAP00000041572 | Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. | Glucagon. | 0.872 |
DPP4 | GCGR | ENSMFAP00000029520 | ENSMFAP00000013821 | Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. | Glucagon receptor; Belongs to the G-protein coupled receptor 2 family. | 0.770 |
DPP4 | GHRL | ENSMFAP00000029520 | ENSMFAP00000024146 | Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. | Ghrelin and obestatin prepropeptide. | 0.660 |
DPP4 | GIPR | ENSMFAP00000029520 | ENSMFAP00000022679 | Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. | Gastric inhibitory polypeptide receptor; Belongs to the G-protein coupled receptor 2 family. | 0.756 |
DPP4 | GLP1R | ENSMFAP00000029520 | ENSMFAP00000035347 | Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. | Glucagon-like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. | 0.897 |
DPP4 | INS | ENSMFAP00000029520 | ENSMFAP00000009056 | Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.789 |
DPP4 | LEP | ENSMFAP00000029520 | ENSMFAP00000024992 | Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.670 |
DPP4 | PPARG | ENSMFAP00000029520 | ENSMFAP00000035941 | Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.459 |
DPP4 | PYY | ENSMFAP00000029520 | ENSMFAP00000001715 | Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. | Peptide YY. | 0.647 |
ENSMFAP00000020437 | ALB | ENSMFAP00000020437 | ENSMFAP00000002887 | Aspartate aminotransferase. | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | 0.921 |