(31 nodes) (2021) The Safe Path at the Fork: Ensuring Replication-Associated DNA Double-Strand Breaks are Repaired by Homologous Recombination. network (Gallus gallus)

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Predicted Interactions

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protein homology

Your Input:
	CDC45	Cell division cycle 45. (566 aa)
	EME2	Essential meiotic structure-specific endonuclease subunit 2. (273 aa)
	CLSPN	Uncharacterized protein. (1337 aa)
	BRCA1	Uncharacterized protein. (1749 aa)
	FANCD2	Uncharacterized protein. (1510 aa)
	DNA2	DNA replication ATP-dependent helicase/nuclease DNA2; Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by [...] (992 aa)
	RADX	RPA1 related single stranded DNA binding protein, X-linked. (852 aa)
	EXO1	Uncharacterized protein. (800 aa)
	USP1	Ubiquitin carboxyl-terminal hydrolase. (794 aa)
	SMC5	Structural maintenance of chromosomes protein 5; Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; [...] (1065 aa)
	LIG4	DNA ligase 4; Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. (912 aa)
	BRCA2	Tower domain-containing protein. (3397 aa)
	RAD51AP1	Uncharacterized protein. (255 aa)
	POLD3	DNA polymerase delta subunit 3; Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex. As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair. Required for optimal Pol-delta activity. Stabilizes the Pol-delta complex and plays a major role in Pol-delta stimulation by PCNA. Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences [...] (467 aa)
	RAD54L	DNA repair and recombination protein RAD54-like; Involved in DNA repair and mitotic recombination; Belongs to the SNF2/RAD54 helicase family. (804 aa)
	RAD50	Zinc-hook domain-containing protein. (1313 aa)
	XRCC2	X-ray repair cross complementing 2. (279 aa)
	EEPD1	Endonuclease/exonuclease/phosphatase family domain containing 1. (558 aa)
	PRIM1	DNA primase; Belongs to the eukaryotic-type primase small subunit family. (431 aa)
	RAD51	DNA repair protein RAD51 homolog 1; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. (339 aa)
	TOPBP1	DNA topoisomerase II binding protein 1. (1519 aa)
	RAD54B	DNA repair and recombination protein RAD54B; Involved in DNA repair and mitotic recombination; Belongs to the SNF2/RAD54 helicase family. (918 aa)
	MRNIP	Uncharacterized protein. (356 aa)
	XRCC6	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic s [...] (647 aa)
	CDC25A	Rhodanese domain-containing protein. (526 aa)
	RAD52	DNA repair protein RAD52 homolog; Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase (By similarity). (422 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (262 aa)
	PRIMPOL	DNA-directed primase/polymerase protein; DNA primase and DNA polymerase required to tolerate replication-stalling lesions by bypassing them. Required to facilitate mitochondrial and nuclear replication fork progression by initiating de novo DNA synthesis using dNTPs and acting as an error-prone DNA polymerase able to bypass certain DNA lesions. Shows a high capacity to tolerate DNA damage lesions such as 8oxoG and abasic sites in DNA (By similarity). Provides different translesion synthesis alternatives when DNA replication is stalled: able to synthesize DNA primers downstream of lesio [...] (574 aa)
	NUCKS1	Uncharacterized protein. (355 aa)
	REV1	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents (By similarity). May play a role in homologous recombination and immunoglobulin gene conversion; Belongs to the DNA polymerase type-Y family. (1276 aa)
	RAD51B	RAD51 paralog B. (415 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRCA1	BRCA2	ENSGALP00000004383	ENSGALP00000027524	Uncharacterized protein.	Tower domain-containing protein.	0.999
BRCA1	CDC25A	ENSGALP00000004383	ENSGALP00000057880	Uncharacterized protein.	Rhodanese domain-containing protein.	0.666
BRCA1	CDC45	ENSGALP00000004383	ENSGALP00000002461	Uncharacterized protein.	Cell division cycle 45.	0.735
BRCA1	CLSPN	ENSGALP00000004383	ENSGALP00000003690	Uncharacterized protein.	Uncharacterized protein.	0.884
BRCA1	DNA2	ENSGALP00000004383	ENSGALP00000006419	Uncharacterized protein.	DNA replication ATP-dependent helicase/nuclease DNA2; Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by [...]	0.957
BRCA1	EEPD1	ENSGALP00000004383	ENSGALP00000044398	Uncharacterized protein.	Endonuclease/exonuclease/phosphatase family domain containing 1.	0.538
BRCA1	EXO1	ENSGALP00000004383	ENSGALP00000017465	Uncharacterized protein.	Uncharacterized protein.	0.969
BRCA1	FANCD2	ENSGALP00000004383	ENSGALP00000005896	Uncharacterized protein.	Uncharacterized protein.	0.993
BRCA1	LIG4	ENSGALP00000004383	ENSGALP00000027179	Uncharacterized protein.	DNA ligase 4; Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination.	0.837
BRCA1	PCNA	ENSGALP00000004383	ENSGALP00000064149	Uncharacterized protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.512
BRCA1	PRIMPOL	ENSGALP00000004383	ENSGALP00000065409	Uncharacterized protein.	DNA-directed primase/polymerase protein; DNA primase and DNA polymerase required to tolerate replication-stalling lesions by bypassing them. Required to facilitate mitochondrial and nuclear replication fork progression by initiating de novo DNA synthesis using dNTPs and acting as an error-prone DNA polymerase able to bypass certain DNA lesions. Shows a high capacity to tolerate DNA damage lesions such as 8oxoG and abasic sites in DNA (By similarity). Provides different translesion synthesis alternatives when DNA replication is stalled: able to synthesize DNA primers downstream of lesio [...]	0.698
BRCA1	RAD50	ENSGALP00000004383	ENSGALP00000039135	Uncharacterized protein.	Zinc-hook domain-containing protein.	0.946
BRCA1	RAD51	ENSGALP00000004383	ENSGALP00000046453	Uncharacterized protein.	DNA repair protein RAD51 homolog 1; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange.	0.997
BRCA1	RAD51AP1	ENSGALP00000004383	ENSGALP00000027892	Uncharacterized protein.	Uncharacterized protein.	0.784
BRCA1	RAD51B	ENSGALP00000004383	ENSGALP00000068967	Uncharacterized protein.	RAD51 paralog B.	0.943
BRCA1	RAD52	ENSGALP00000004383	ENSGALP00000063584	Uncharacterized protein.	DNA repair protein RAD52 homolog; Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase (By similarity).	0.960
BRCA1	RAD54B	ENSGALP00000004383	ENSGALP00000052510	Uncharacterized protein.	DNA repair and recombination protein RAD54B; Involved in DNA repair and mitotic recombination; Belongs to the SNF2/RAD54 helicase family.	0.820
BRCA1	RAD54L	ENSGALP00000004383	ENSGALP00000037559	Uncharacterized protein.	DNA repair and recombination protein RAD54-like; Involved in DNA repair and mitotic recombination; Belongs to the SNF2/RAD54 helicase family.	0.888
BRCA1	RADX	ENSGALP00000004383	ENSGALP00000014607	Uncharacterized protein.	RPA1 related single stranded DNA binding protein, X-linked.	0.628
BRCA1	REV1	ENSGALP00000004383	ENSGALP00000066817	Uncharacterized protein.	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents (By similarity). May play a role in homologous recombination and immunoglobulin gene conversion; Belongs to the DNA polymerase type-Y family.	0.556