(21 nodes) (2016) Differential Gene Expression Patterns in Chicken Cardiomyocytes during Hydrogen Peroxide-Induced Apoptosis. network (Gallus gallus)

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Known Interactions

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Predicted Interactions

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Your Input:
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (418 aa)
	CAAP1	Caspase activity and apoptosis inhibitor 1. (299 aa)
	CFLAR	Uncharacterized protein; Belongs to the peptidase C14A family. (493 aa)
	CASP8	Uncharacterized protein; Belongs to the peptidase C14A family. (482 aa)
	CASP7	Caspase 7; Belongs to the peptidase C14A family. (309 aa)
	SOD2	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (224 aa)
	CASP6	Uncharacterized protein; Belongs to the peptidase C14A family. (317 aa)
	BCL2	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (233 aa)
	FOXO3	Forkhead box O3. (660 aa)
	CASP2	Caspase-2 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. (441 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (385 aa)
	TNFRSF1A	Uncharacterized protein. (427 aa)
	BAK1	Uncharacterized protein. (216 aa)
	HOXD12	Homeobox protein Hox-D12; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (266 aa)
	CASP10	Caspase 10; Belongs to the peptidase C14A family. (455 aa)
	FGF10	Uncharacterized protein. (261 aa)
	ACTA2	Actin, aortic smooth muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. (377 aa)
	CASP3	Caspase-3; Belongs to the peptidase C14A family. (283 aa)
	EGLN1	Uncharacterized protein. (443 aa)
	BFAR	Bifunctional apoptosis regulator. (449 aa)
	API5	Apoptosis inhibitor 5; Antiapoptotic factor that may have a role in protein assembly. (526 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTA2	CASP3	ENSGALP00000067749	ENSGALP00000068843	Actin, aortic smooth muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family.	Caspase-3; Belongs to the peptidase C14A family.	0.475
API5	BFAR	ENSGALP00000070843	ENSGALP00000069703	Apoptosis inhibitor 5; Antiapoptotic factor that may have a role in protein assembly.	Bifunctional apoptosis regulator.	0.609
API5	CAAP1	ENSGALP00000070843	ENSGALP00000002706	Apoptosis inhibitor 5; Antiapoptotic factor that may have a role in protein assembly.	Caspase activity and apoptosis inhibitor 1.	0.742
API5	CASP2	ENSGALP00000070843	ENSGALP00000029853	Apoptosis inhibitor 5; Antiapoptotic factor that may have a role in protein assembly.	Caspase-2 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.	0.454
BAK1	BCL2	ENSGALP00000055311	ENSGALP00000020984	Uncharacterized protein.	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	0.985
BAK1	CASP3	ENSGALP00000055311	ENSGALP00000068843	Uncharacterized protein.	Caspase-3; Belongs to the peptidase C14A family.	0.751
BAK1	CASP6	ENSGALP00000055311	ENSGALP00000019870	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.401
BAK1	CASP7	ENSGALP00000055311	ENSGALP00000014503	Uncharacterized protein.	Caspase 7; Belongs to the peptidase C14A family.	0.585
BAK1	CASP8	ENSGALP00000055311	ENSGALP00000013591	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.669
BAK1	CASP9	ENSGALP00000055311	ENSGALP00000002083	Uncharacterized protein.	Caspase 9; Belongs to the peptidase C14A family.	0.757
BAK1	CFLAR	ENSGALP00000055311	ENSGALP00000013394	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.457
BCL2	BAK1	ENSGALP00000020984	ENSGALP00000055311	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Uncharacterized protein.	0.985
BCL2	CASP10	ENSGALP00000020984	ENSGALP00000062992	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Caspase 10; Belongs to the peptidase C14A family.	0.679
BCL2	CASP2	ENSGALP00000020984	ENSGALP00000029853	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Caspase-2 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.	0.767
BCL2	CASP3	ENSGALP00000020984	ENSGALP00000068843	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Caspase-3; Belongs to the peptidase C14A family.	0.989
BCL2	CASP6	ENSGALP00000020984	ENSGALP00000019870	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Uncharacterized protein; Belongs to the peptidase C14A family.	0.765
BCL2	CASP7	ENSGALP00000020984	ENSGALP00000014503	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Caspase 7; Belongs to the peptidase C14A family.	0.800
BCL2	CASP8	ENSGALP00000020984	ENSGALP00000013591	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Uncharacterized protein; Belongs to the peptidase C14A family.	0.967
BCL2	CASP9	ENSGALP00000020984	ENSGALP00000002083	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Caspase 9; Belongs to the peptidase C14A family.	0.984
BCL2	CFLAR	ENSGALP00000020984	ENSGALP00000013394	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Uncharacterized protein; Belongs to the peptidase C14A family.	0.540