41 items (Anas platyrhynchos) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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experimentally determined

Predicted Interactions

gene neighborhood

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textmining

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protein homology

Your Input:
	TFAM	Transcription factor A, mitochondrial. (379 aa)
	CUL3	Cullin 3; Belongs to the cullin family. (1175 aa)
	ENSAPLP00000032061	Uncharacterized protein. (900 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	BAK1	BCL2 antagonist/killer 1. (306 aa)
	EGFR	Receptor protein-tyrosine kinase. (1219 aa)
	BECN1	Uncharacterized protein. (452 aa)
	PINK1	PTEN induced kinase 1. (603 aa)
	CCR7	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (374 aa)
	HMOX1	Heme oxygenase 1. (296 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (446 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (450 aa)
	RBX1	Ring-box 1. (108 aa)
	TLR2	Toll like receptor 2; Belongs to the Toll-like receptor family. (713 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	MFN1	Mitofusin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (743 aa)
	TLR4	Toll like receptor 4. (843 aa)
	U3J1K3_ANAPP	Uncharacterized protein; Belongs to the peptidase C14A family. (284 aa)
	IDH1	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (415 aa)
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (466 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (306 aa)
	U3J6D9_ANAPP	Uncharacterized protein; Belongs to the peptidase C14A family. (457 aa)
	IL10	Interleukin 10. (177 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (690 aa)
	NQO1	NAD(P)H quinone dehydrogenase 1. (346 aa)
	BCL2A1	BCL2 related protein A1. (172 aa)
	CD4	Ig-like domain-containing protein. (264 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (315 aa)
	ATG7	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (735 aa)
	GCLC	Glutamate-cysteine ligase catalytic subunit. (688 aa)
	BCL2	BCL2 apoptosis regulator. (239 aa)
	IL6	Uncharacterized protein. (350 aa)
	IDH2	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (400 aa)
	ENSAPLP00000023999	PAS domain-containing protein. (956 aa)
	BCL2L1	BCL2 like 1. (238 aa)
	IRF7	Interferon regulatory factor 7. (523 aa)
	NRF1	Nuclear respiratory factor 1. (487 aa)
	AHR	Uncharacterized protein. (834 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (311 aa)
	NOX4	NADPH oxidase 4. (626 aa)
	CCL20	C-C motif chemokine. (98 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG5	ATG7	ENSAPLP00000018253	ENSAPLP00000019209	Autophagy protein 5; Involved in autophagic vesicle formation.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	0.999
ATG5	BCL2	ENSAPLP00000018253	ENSAPLP00000019939	Autophagy protein 5; Involved in autophagic vesicle formation.	BCL2 apoptosis regulator.	0.713
ATG5	BCL2L1	ENSAPLP00000018253	ENSAPLP00000025626	Autophagy protein 5; Involved in autophagic vesicle formation.	BCL2 like 1.	0.613
ATG5	BECN1	ENSAPLP00000018253	ENSAPLP00000004076	Autophagy protein 5; Involved in autophagic vesicle formation.	Uncharacterized protein.	0.982
ATG5	CASP3	ENSAPLP00000018253	ENSAPLP00000015062	Autophagy protein 5; Involved in autophagic vesicle formation.	Caspase 3; Belongs to the peptidase C14A family.	0.714
ATG5	CASP8	ENSAPLP00000018253	ENSAPLP00000014720	Autophagy protein 5; Involved in autophagic vesicle formation.	Caspase 8; Belongs to the peptidase C14A family.	0.681
ATG5	CASP9	ENSAPLP00000018253	ENSAPLP00000008534	Autophagy protein 5; Involved in autophagic vesicle formation.	Caspase 9; Belongs to the peptidase C14A family.	0.402
ATG5	MFN1	ENSAPLP00000018253	ENSAPLP00000012358	Autophagy protein 5; Involved in autophagic vesicle formation.	Mitofusin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.733
ATG5	PINK1	ENSAPLP00000018253	ENSAPLP00000007324	Autophagy protein 5; Involved in autophagic vesicle formation.	PTEN induced kinase 1.	0.671
ATG5	RIPK1	ENSAPLP00000018253	ENSAPLP00000015290	Autophagy protein 5; Involved in autophagic vesicle formation.	Receptor interacting serine/threonine kinase 1.	0.494
ATG5	U3J6D9_ANAPP	ENSAPLP00000018253	ENSAPLP00000015066	Autophagy protein 5; Involved in autophagic vesicle formation.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.682
ATG7	ATG5	ENSAPLP00000019209	ENSAPLP00000018253	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	Autophagy protein 5; Involved in autophagic vesicle formation.	0.999
ATG7	BCL2	ENSAPLP00000019209	ENSAPLP00000019939	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	BCL2 apoptosis regulator.	0.526
ATG7	BECN1	ENSAPLP00000019209	ENSAPLP00000004076	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	Uncharacterized protein.	0.947
ATG7	CASP3	ENSAPLP00000019209	ENSAPLP00000015062	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	Caspase 3; Belongs to the peptidase C14A family.	0.570
ATG7	CASP9	ENSAPLP00000019209	ENSAPLP00000008534	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	Caspase 9; Belongs to the peptidase C14A family.	0.462
ATG7	CUL3	ENSAPLP00000019209	ENSAPLP00000032353	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	Cullin 3; Belongs to the cullin family.	0.570
ATG7	PINK1	ENSAPLP00000019209	ENSAPLP00000007324	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	PTEN induced kinase 1.	0.603
ATG7	RBX1	ENSAPLP00000019209	ENSAPLP00000010158	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	Ring-box 1.	0.413
BAK1	BCL2	ENSAPLP00000002503	ENSAPLP00000019939	BCL2 antagonist/killer 1.	BCL2 apoptosis regulator.	0.981