STRINGSTRING
sirt1 sirt1 rapgef2 rapgef2 il10 il10 fadd fadd LOC100490663 LOC100490663 fnip1 fnip1 HSH2D HSH2D kifap3 kifap3 anxa1.1 anxa1.1 mertk mertk SLC7A11 SLC7A11 lyn lyn tp53 tp53 gas6 gas6 aurkb aurkb bcl11b bcl11b axl axl DOCK8 DOCK8 blk blk noc2l noc2l LOC100490493 LOC100490493 pik3cb pik3cb lgals3 lgals3 bcl10 bcl10 bax bax anxa1.3 anxa1.3 prelid1 prelid1 efna1 efna1 p2rx7 p2rx7 LOC100490828 LOC100490828 ENSXETP00000015888 ENSXETP00000015888 cd74 cd74 NF1 NF1 slc46a2 slc46a2 ENSXETP00000019044 ENSXETP00000019044 LOC100487203 LOC100487203 dtnb-2 dtnb-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
sirt1Thrombospondin-type laminin G domain and EAR repeats. (707 aa)
rapgef2Cathepsin K-like. (1670 aa)
il10Activating transcription factor 6. (172 aa)
faddZinc finger, NFX1-type containing 1, gene 2. (188 aa)
LOC100490663Uncharacterized protein; Belongs to the protein kinase superfamily. (439 aa)
fnip1cAMP-responsive element modulator. (1163 aa)
HSH2DHematopoietic SH2 domain containing. (363 aa)
kifap3Uncharacterized protein. (808 aa)
anxa1.1Annexin. (675 aa)
mertkZona pellucida protein D. (946 aa)
SLC7A11Solute carrier family 7 member 11. (500 aa)
lynTyrosine-protein kinase. (524 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (362 aa)
gas6Homeobox protein CDX-1. (672 aa)
aurkbAurora kinase B; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of [...] (375 aa)
bcl11bAquaporin 7. (829 aa)
axlUncharacterized protein. (914 aa)
DOCK8Dedicator of cytokinesis 8; Belongs to the DOCK family. (2040 aa)
blkTyrosine-protein kinase. (497 aa)
noc2lPolycomb group ring finger 6. (840 aa)
LOC100490493Coiled-coil-helix-coiled-coil-helix domain containing 2; Belongs to the protein kinase superfamily. (421 aa)
pik3cbSolute carrier family 27 member 6; Belongs to the PI3/PI4-kinase family. (1085 aa)
lgals3Galectin. (256 aa)
bcl10Solute carrier family 35 (GDP-fucose transporter), member C2. (236 aa)
baxBCL2-associated X protein. (221 aa)
anxa1.3Annexin. (350 aa)
prelid1Janus kinase 3 (a protein tyrosine kinase, leukocyte). (216 aa)
efna1Ephrin RBD domain-containing protein; Belongs to the ephrin family. (146 aa)
p2rx7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (558 aa)
LOC100490828P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (559 aa)
ENSXETP00000015888H2A histone family member Y2. (241 aa)
cd74Synovial sarcoma translocation gene on chromosome 18-like 1. (291 aa)
NF1Neurofibromin 1. (2812 aa)
slc46a2Uncharacterized protein. (444 aa)
ENSXETP00000019044Uncharacterized protein. (460 aa)
LOC100487203Uncharacterized protein. (466 aa)
dtnb-2Dystrobrevin beta. (329 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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