STRINGSTRING
ccr2-2 ccr2-2 nrp1a nrp1a il1b il1b ASS1 ASS1 tlr1 tlr1 ctnnb1 ctnnb1 faslg faslg igfbp1a igfbp1a nos1 nos1 pdia3 pdia3 hmgb1a hmgb1a itgam itgam ppargc1b ppargc1b itga4 itga4 p2ry12 p2ry12 nf1a nf1a zgc:162611-2 zgc:162611-2 egfra egfra gdnfa gdnfa ccl20b ccl20b tgfb1b tgfb1b lrig2 lrig2 thbs1b thbs1b il15 il15 slc2a5 slc2a5 tgfbr1a tgfbr1a cd44a cd44a aqp1a.2 aqp1a.2 cxcl14 cxcl14 igfbp6b igfbp6b hoxc6a hoxc6a nos2a nos2a mtor mtor mfsd10 mfsd10 lpcat3 lpcat3 sall1a sall1a myca myca slco4a1 slco4a1 il10 il10 tgfb5 tgfb5 ptprc ptprc mif mif stat3 stat3 wasla wasla pdgfra pdgfra pik3c3 pik3c3 h3f3a-2 h3f3a-2 wnt3a wnt3a nrp1b nrp1b sirt1 sirt1 gpnmb gpnmb zgc:113983 zgc:113983 olfml3b olfml3b il11b il11b cxcr2 cxcr2 egf egf slc30a5 slc30a5 zgc:173552 zgc:173552 mmp9 mmp9 selp selp cxcr4b cxcr4b ccl38a.5 ccl38a.5 tgfb1a tgfb1a apoeb apoeb acta1b acta1b cnr2 cnr2 ptk2bb ptk2bb tlr2 tlr2 cxcl12a cxcl12a nos2b nos2b tgfb3 tgfb3 slit2 slit2 idh2 idh2 wt1a wt1a ifnphi1 ifnphi1 aqp1a.1 aqp1a.1 jade1 jade1 ptk2ab ptk2ab slc2a15a slc2a15a igf1rb igf1rb enpp2 enpp2 arntl1a arntl1a waslb waslb mmp2 mmp2 btg2 btg2 cnr1 cnr1 tnfb tnfb robo2 robo2 tlr3 tlr3 igf1ra igf1ra acp5a acp5a ezh2 ezh2 idh1 idh1 pdcd10a pdcd10a il6r il6r igfbp6a igfbp6a pdgfrb pdgfrb MCOLN3 MCOLN3 tlr9 tlr9 csf1ra csf1ra robo2-2 robo2-2 lrp8 lrp8 hist2h3ca1 hist2h3ca1 ccr2 ccr2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ccr2-2Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family. (360 aa)
nrp1aNeuropilin-1a; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. Regulates angiogenesis through a VEGF-dependent pathway. (923 aa)
il1bInterleukin-1. (284 aa)
ASS1Argininosuccinate synthase; One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues; Belongs to the argininosuccinate synthase family. (302 aa)
tlr1Toll-like receptor 1; Belongs to the Toll-like receptor family. (795 aa)
ctnnb1Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] (789 aa)
faslgFas ligand (TNF superfamily, member 6); Belongs to the tumor necrosis factor family. (268 aa)
igfbp1aInsulin-like growth factor-binding protein 1a. (262 aa)
nos1Nitric oxide synthase; Produces nitric oxide (NO). (1431 aa)
pdia3Protein disulfide-isomerase. (459 aa)
hmgb1aHigh mobility group box 1a. (205 aa)
itgamIntegrin, alpha M (complement component 3 receptor 3 subunit); Belongs to the integrin alpha chain family. (780 aa)
ppargc1bPeroxisome proliferator-activated receptor gamma, coactivator 1 beta. (847 aa)
itga4Integrin alpha 4; Belongs to the integrin alpha chain family. (1018 aa)
p2ry12G protein-coupled purinergic receptor p2y 12. (345 aa)
nf1aNeurofibromin 1a. (2759 aa)
zgc:162611-2Si:dkey-108k21.24. (151 aa)
egfraEpidermal growth factor receptor precursor. (625 aa)
gdnfaGlial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake (By similarity). Essential for the development of the enteric nervous system, but appears dispensable for the development of the kidney and primary motor neuron; Belongs to the TGF-beta family. GDNF subfamily. (235 aa)
ccl20bC-C motif chemokine. (102 aa)
tgfb1bTransforming growth factor beta; Belongs to the TGF-beta family. (379 aa)
lrig2Leucine-rich repeats and immunoglobulin-like domains 2. (1018 aa)
thbs1bThrombospondin 1b. (1171 aa)
il15Interleukin; Belongs to the IL-15/IL-21 family. (193 aa)
slc2a5Solute carrier family 2 member 5; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (511 aa)
tgfbr1aReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (500 aa)
cd44aCD44 molecule (Indian blood group) a. (392 aa)
aqp1a.2Aquaporin 1a (Colton blood group), tandem duplicate 2; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
cxcl14Chemokine (C-X-C motif) ligand 14. (100 aa)
igfbp6bInsulin-like growth factor-binding protein 6b. (212 aa)
hoxc6aHomeobox protein Hox-C6a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (208 aa)
nos2aNitric oxide synthase; Produces nitric oxide (NO). (1079 aa)
mtorSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2563 aa)
mfsd10Major facilitator superfamily domain-containing 10. (450 aa)
lpcat3Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (465 aa)
sall1aSpalt-like transcription factor 1a. (1313 aa)
mycaTranscriptional regulator Myc-A; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (409 aa)
slco4a1Solute carrier organic anion transporter family member. (742 aa)
il10Interleukin-10. (180 aa)
tgfb5Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
ptprcProtein tyrosine phosphatase receptor type C. (1130 aa)
mifMacrophage migration inhibitory factor. (115 aa)
stat3Signal transducer and activator of transcription. (806 aa)
waslaWASP-like actin nucleation-promoting factor a. (502 aa)
pdgfraPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for pdgfa, pdgfb and pdgfc and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. Required for normal development of the gastrointestinal tract. Plays a role in cell migration and chemotaxis in wound [...] (1456 aa)
pik3c3Phosphatidylinositol 3-kinase catalytic subunit type 3. (878 aa)
h3f3a-2Histone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] (136 aa)
wnt3aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
nrp1bNeuropilin 1b. (540 aa)
sirt1Sirtuin 1. (710 aa)
gpnmbGlycoprotein (transmembrane) nmb. (627 aa)
zgc:113983Histone H3.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (136 aa)
olfml3bOlfactomedin-like protein 3A; Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity); Belongs to the OLFML3 family. (390 aa)
il11bInterleukin 11b. (192 aa)
cxcr2Chemokine (C-X-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family. (340 aa)
egfEpidermal growth factor. (1114 aa)
slc30a5Zinc transporter 5; Functions as a zinc transporter. Partly regulates cellular zinc homeostasis (By similarity). (775 aa)
zgc:173552Histone H3; Belongs to the histone H3 family. (136 aa)
mmp9Matrix metallopeptidase 9. (680 aa)
selpSelectin P. (868 aa)
cxcr4bChemokine (C-X-C motif), receptor 4b; Belongs to the G-protein coupled receptor 1 family. (353 aa)
ccl38a.5C-C motif chemokine. (103 aa)
tgfb1aTransforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
apoebApolipoprotein Eb; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. Belongs to the apolipoprotein A1/A4/E family. (281 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
cnr2Cannabinoid receptor 2; Belongs to the G-protein coupled receptor 1 family. (383 aa)
ptk2bbProtein tyrosine kinase 2 beta, b; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1004 aa)
tlr2Toll-like receptor 2. (788 aa)
cxcl12aChemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1); Belongs to the intercrine alpha (chemokine CxC) family. (99 aa)
nos2bNitric oxide synthase; Produces nitric oxide (NO). (1077 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
slit2Slit homolog 2 (Drosophila). (1512 aa)
idh2Isocitrate dehydrogenase (NADP(+)) 2. (225 aa)
wt1aWT1 transcription factor a. (419 aa)
ifnphi1Interferon phi 1. (185 aa)
aqp1a.1Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (260 aa)
jade1Protein Jade-1; Transcriptional coactivator which seems to act by promoting acetylation of nucleosomal histone H4 by kat5. Promotes apoptosis (By similarity). (829 aa)
ptk2abProtein tyrosine kinase 2ab; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1050 aa)
slc2a15aSolute carrier family 2 member 15a; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (522 aa)
igf1rbTyrosine-protein kinase receptor. (1380 aa)
enpp2Ectonucleotide pyrophosphatase/phosphodiesterase 2. (850 aa)
arntl1aAryl hydrocarbon receptor nuclear translocator-like 1a. (626 aa)
waslbWASP-like actin nucleation-promoting factor b. (518 aa)
mmp2Matrix metalloproteinase 2. (657 aa)
btg2Anti-proliferative cofactor. (165 aa)
cnr1Cannabinoid receptor; Involved in cannabinoid-induced CNS effects. Belongs to the G-protein coupled receptor 1 family. (475 aa)
tnfbTumor necrosis factor b (TNF superfamily, member 2). (242 aa)
robo2Roundabout, axon guidance receptor, homolog 2 (Drosophila). (1387 aa)
tlr3Toll-like receptor 3; Belongs to the Toll-like receptor family. (903 aa)
igf1raTyrosine-protein kinase receptor. (1405 aa)
acp5aTartrate-resistant acid phosphatase type 5. (339 aa)
ezh2Histone-lysine N-methyltransferase EZH2; Polycomb group (PcG) protein. Catalytic subunit of the prc2/eed-ezh2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. May regulate the circadian clock via histone methylation at the promoter of the circadian genes; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily. (760 aa)
idh1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (429 aa)
pdcd10aProgrammed cell death protein 10-A; Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). Required for normal cardiovascular development. (210 aa)
il6rInterleukin 6 receptor. (604 aa)
igfbp6aInsulin-like growth factor-binding protein 6a. (195 aa)
pdgfrbPlatelet-derived growth factor receptor, beta polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1072 aa)
MCOLN3Mucolipin 3. (595 aa)
tlr9Toll-like receptor 9; Belongs to the Toll-like receptor family. (1069 aa)
csf1raMacrophage colony-stimulating factor 1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Promotes reorganization of the ac [...] (977 aa)
robo2-2Roundabout, axon guidance receptor, homolog 2 (Drosophila). (136 aa)
lrp8Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor. (984 aa)
hist2h3ca1Histone H3; Belongs to the histone H3 family. (136 aa)
ccr2Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family. (354 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (14%) [HD]