(45 nodes) ROS and RNS production in phagocytes network (Piloderma croceum)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A0C3BR19	NAD_binding_2 domain-containing protein. (368 aa)
	A0A0C3BB97	Uncharacterized protein. (80 aa)
	A0A0C3BB75	Uncharacterized protein. (935 aa)
	A0A0C3B4E4	Uncharacterized protein. (979 aa)
	A0A0C3AX06	NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (732 aa)
	A0A0C3AVQ4	Uncharacterized protein. (246 aa)
	A0A0C3AV74	Uncharacterized protein. (185 aa)
	A0A0C3AV21	Uncharacterized protein. (913 aa)
	A0A0C3ARI7	Uncharacterized protein. (894 aa)
	A0A0C3ALL2	ATP-synt_C domain-containing protein; Belongs to the V-ATPase proteolipid subunit family. (82 aa)
	A0A0C3BS72	V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. The active enzyme consists of a catalytic V1 domain attached to an integral membrane V0 proton pore complex. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores; Belongs to the V-ATPase V0D/AC39 subunit family. (355 aa)
	A0A0C3AJN2	Uncharacterized protein. (438 aa)
	A0A0C3ALI3	Uncharacterized protein. (947 aa)
	PILCRDRAFT_324	Uncharacterized protein. (393 aa)
	A0A0C3GC83	Uncharacterized protein. (1707 aa)
	A0A0C3GAM6	Uncharacterized protein. (617 aa)
	A0A0C3G6G7	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (838 aa)
	A0A0C3FYQ7	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (159 aa)
	A0A0C3FY07	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (391 aa)
	A0A0C3FXD2	NAD_binding_11 domain-containing protein. (183 aa)
	A0A0C3FSN0	Uncharacterized protein. (251 aa)
	A0A0C3FS36	Uncharacterized protein. (897 aa)
	A0A0C3FL76	Uncharacterized protein. (897 aa)
	A0A0C3FEU8	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (120 aa)
	A0A0C3FAG2	Uncharacterized protein. (227 aa)
	A0A0C3F7N5	Uncharacterized protein. (321 aa)
	A0A0C3F5B7	Uncharacterized protein. (248 aa)
	A0A0C3F447	Uncharacterized protein. (185 aa)
	A0A0C3F198	Uncharacterized protein. (969 aa)
	A0A0C3EZ77	Uncharacterized protein. (229 aa)
	A0A0C3EVJ6	Uncharacterized protein. (218 aa)
	A0A0C3EV90	Uncharacterized protein. (560 aa)
	A0A0C3EU00	Uncharacterized protein; Belongs to the V-ATPase proteolipid subunit family. (216 aa)
	A0A0C3ENP0	Uncharacterized protein. (945 aa)
	A0A0C3EGH2	Uncharacterized protein. (158 aa)
	A0A0C3CPS8	Uncharacterized protein. (74 aa)
	A0A0C3CAF9	Uncharacterized protein. (814 aa)
	A0A0C3C739	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa)
	A0A0C3BWC3	Uncharacterized protein. (977 aa)
	A0A0C3BCM8	Uncharacterized protein. (350 aa)
	A0A0C3BDD5	Uncharacterized protein. (63 aa)
	A0A0C3BJY9	Uncharacterized protein. (120 aa)
	A0A0C3BMF1	V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (437 aa)
	A0A0C3BNR9	Uncharacterized protein. (397 aa)
	A0A0C3BR14	Uncharacterized protein. (367 aa)

Your Current Organism:

Piloderma croceum

NCBI taxonomy Id: 765440
Other names: P. croceum F 1598, Piloderma croceum F 1598

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A0C3AJN2	A0A0C3BCM8	A0A0C3AJN2	A0A0C3BCM8	Uncharacterized protein.	Uncharacterized protein.	0.838
A0A0C3AJN2	A0A0C3BDD5	A0A0C3AJN2	A0A0C3BDD5	Uncharacterized protein.	Uncharacterized protein.	0.899
A0A0C3AJN2	A0A0C3BMF1	A0A0C3AJN2	A0A0C3BMF1	Uncharacterized protein.	V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.	0.909
A0A0C3AJN2	A0A0C3BR14	A0A0C3AJN2	A0A0C3BR14	Uncharacterized protein.	Uncharacterized protein.	0.667
A0A0C3AJN2	A0A0C3BR19	A0A0C3AJN2	A0A0C3BR19	Uncharacterized protein.	NAD_binding_2 domain-containing protein.	0.667
A0A0C3AJN2	A0A0C3BS72	A0A0C3AJN2	A0A0C3BS72	Uncharacterized protein.	V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. The active enzyme consists of a catalytic V1 domain attached to an integral membrane V0 proton pore complex. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores; Belongs to the V-ATPase V0D/AC39 subunit family.	0.961
A0A0C3AJN2	A0A0C3C739	A0A0C3AJN2	A0A0C3C739	Uncharacterized protein.	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.931
A0A0C3AJN2	A0A0C3CPS8	A0A0C3AJN2	A0A0C3CPS8	Uncharacterized protein.	Uncharacterized protein.	0.931
A0A0C3AJN2	A0A0C3EU00	A0A0C3AJN2	A0A0C3EU00	Uncharacterized protein.	Uncharacterized protein; Belongs to the V-ATPase proteolipid subunit family.	0.946
A0A0C3AJN2	A0A0C3F5B7	A0A0C3AJN2	A0A0C3F5B7	Uncharacterized protein.	Uncharacterized protein.	0.838
A0A0C3AJN2	A0A0C3FAG2	A0A0C3AJN2	A0A0C3FAG2	Uncharacterized protein.	Uncharacterized protein.	0.961
A0A0C3AJN2	A0A0C3FEU8	A0A0C3AJN2	A0A0C3FEU8	Uncharacterized protein.	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.905
A0A0C3AJN2	A0A0C3FSN0	A0A0C3AJN2	A0A0C3FSN0	Uncharacterized protein.	Uncharacterized protein.	0.950
A0A0C3AJN2	A0A0C3FXD2	A0A0C3AJN2	A0A0C3FXD2	Uncharacterized protein.	NAD_binding_11 domain-containing protein.	0.667
A0A0C3AJN2	A0A0C3FY07	A0A0C3AJN2	A0A0C3FY07	Uncharacterized protein.	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.908
A0A0C3AJN2	A0A0C3FYQ7	A0A0C3AJN2	A0A0C3FYQ7	Uncharacterized protein.	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.834
A0A0C3AJN2	A0A0C3G6G7	A0A0C3AJN2	A0A0C3G6G7	Uncharacterized protein.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.931
A0A0C3AJN2	A0A0C3GAM6	A0A0C3AJN2	A0A0C3GAM6	Uncharacterized protein.	Uncharacterized protein.	0.961
A0A0C3AJN2	A0A0C3GC83	A0A0C3AJN2	A0A0C3GC83	Uncharacterized protein.	Uncharacterized protein.	0.960
A0A0C3AJN2	PILCRDRAFT_324	A0A0C3AJN2	A0A0C3GNW9	Uncharacterized protein.	Uncharacterized protein.	0.416