STRINGSTRING
ADZ91435.1 ADZ91435.1 ADZ91339.1 ADZ91339.1 ADZ89365.1 ADZ89365.1 thrB thrB ADZ89974.1 ADZ89974.1 ADZ89975.1 ADZ89975.1 folD folD ADZ90034.1 ADZ90034.1 ADZ90086.1 ADZ90086.1 ADZ90166.1 ADZ90166.1 dapB dapB dapE dapE dapD dapD ADZ90528.1 ADZ90528.1 tdh-2 tdh-2 ADZ90657.1 ADZ90657.1 ADZ90808.1 ADZ90808.1 dapF dapF ADZ91148.1 ADZ91148.1 ADZ91185.1 ADZ91185.1 dapA dapA metXS metXS mtnN mtnN ADZ93190.1 ADZ93190.1 ADZ93177.1 ADZ93177.1 ADZ92949.1 ADZ92949.1 ADZ92561.1 ADZ92561.1 dapA-2 dapA-2 lysA lysA dapF-2 dapF-2 ADZ92067.1 ADZ92067.1 folD-2 folD-2 asd asd
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADZ91435.1PFAM: Cupin 2, conserved barrel; KEGG: mmw:Mmwyl1_2675 cupin 2 domain-containing protein. (343 aa)
ADZ91339.1PFAM: Homocysteine S-methyltransferase; KEGG: mmw:Mmwyl1_2930 homocysteine S-methyltransferase. (303 aa)
ADZ89365.1KEGG: csa:Csal_2487 5-dehydro-4-deoxyglucarate dehydratase; PFAM: Dihydrodipicolinate synthetase; Belongs to the DapA family. (302 aa)
thrBHomoserine kinase; PFAM: Aminoglycoside phosphotransferase; manually curated; KEGG: mmw:Mmwyl1_0284 homoserine kinase; TIGRFAM: Homoserine kinase ThrB; Belongs to the pseudomonas-type ThrB family. (319 aa)
ADZ89974.1KEGG: mmw:Mmwyl1_3765 homoserine dehydrogenase; PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding; Amino acid-binding ACT. (453 aa)
ADZ89975.1TIGRFAM: Threonine synthase; KEGG: mmw:Mmwyl1_3764 threonine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit. (461 aa)
folDBifunctional protein folD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (280 aa)
ADZ90034.1KEGG: mmw:Mmwyl1_3627 aspartate kinase; TIGRFAM: Aspartate kinase domain; Aspartate kinase, monofunctional class; PFAM: Aspartate/glutamate/uridylate kinase; Amino acid-binding ACT; Belongs to the aspartokinase family. (413 aa)
ADZ90086.1Peptidase dimerization domain protein; PFAM: Peptidase M20, dimerisation; Peptidase M20; KEGG: mmw:Mmwyl1_3818 peptidase dimerisation domain-containing protein. (409 aa)
ADZ90166.1TIGRFAM: Lysine-2,3-aminomutase-like; Conserved hyprothetical protein CHP00238, KamA; KEGG: mmw:Mmwyl1_0898 lysine 2,3-aminomutase YodO family protein; PFAM: Radical SAM. (336 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (266 aa)
dapESuccinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (388 aa)
dapD2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (345 aa)
ADZ90528.1PFAM: Asparagine synthase; KEGG: pin:Ping_2657 asparagine synthase. (616 aa)
tdh-2L-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (380 aa)
ADZ90657.1PFAM: Aminoglycoside phosphotransferase; KEGG: mmw:Mmwyl1_0156 hypothetical protein. (547 aa)
ADZ90808.1HAMAP: Fumarate hydratase, class II; KEGG: mmw:Mmwyl1_2652 aspartate ammonia-lyase; PFAM: Lyase 1, N-terminal; Fumarase C, C-terminal. (490 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (276 aa)
ADZ91148.12-hydroxypropyl-CoM lyase; KEGG: cps:CPS_1151 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; PFAM: Methionine synthase, vitamin-B12 independent. (346 aa)
ADZ91185.1Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1244 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa)
metXSHomoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. (385 aa)
mtnN5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (231 aa)
ADZ93190.1KEGG: mmw:Mmwyl1_4225 hypothetical protein; PFAM: Protein of unknown function DUF227; SMART: CHK kinase-like. (338 aa)
ADZ93177.1KEGG: pfs:PFLU2011 homoserine dehydrogenase; PFAM: Homoserine dehydrogenase, catalytic. (385 aa)
ADZ92949.1PFAM: FAD dependent oxidoreductase; KEGG: vcm:VCM66_A0145 hydroxyglutarate oxidase. (402 aa)
ADZ92561.1TIGRFAM: Sialic acid O-acyltransferase, NeuD; KEGG: spl:Spea_0050 sialic acid biosynthesis protein NeuD. (219 aa)
dapA-2Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (290 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (417 aa)
dapF-2Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (278 aa)
ADZ92067.1KEGG: mmw:Mmwyl1_1696 hypothetical protein; Belongs to the methylenetetrahydrofolate reductase family. (318 aa)
folD-2Bifunctional protein folD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (301 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (372 aa)
Your Current Organism:
Marinomonas mediterranea
NCBI taxonomy Id: 717774
Other names: M. mediterranea MMB-1, Marinomonas mediterranea MMB-1, Marinomonas mediterranea str. MMB-1, Marinomonas mediterranea strain MMB-1
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