STRINGSTRING
CBG06982 CBG06982 num-1 num-1 CBG05563 CBG05563 snx-17 snx-17 prhg-1 prhg-1 shc-1 shc-1 unc-112 unc-112 ephx-1 ephx-1 exc-5 exc-5 stn-1 stn-1 cnk-1 cnk-1 mtm-6 mtm-6 CBG24914 CBG24914 CBG00040 CBG00040 dab-1 dab-1 smk-1 smk-1 tbc-9 tbc-9 gtf-2h1 gtf-2h1 rhgf-1 rhgf-1 CBG01639 CBG01639 CBG01565 CBG01565 cgef-1 cgef-1 CBG02248 CBG02248 ani-2 ani-2 ran-5 ran-5 tbc-2 tbc-2 shc-2 shc-2 wdfy-3 wdfy-3 let-502 let-502 obr-4 obr-4 hmg-3 hmg-3 pll-1 pll-1 CBG15618 CBG15618 tns-1 tns-1 mtm-5 mtm-5 apl-1 apl-1 Cbr-tag-52 Cbr-tag-52 CBG14242 CBG14242 gap-1 gap-1 eps-8 eps-8 rga-2 rga-2 efa-6 efa-6 CBG13318 CBG13318 npp-16 npp-16 obr-1 obr-1 CBG12618 CBG12618 CBG03790 CBG03790 erm-1 erm-1 frm-4 frm-4 tiam-1 tiam-1 CBG12078 CBG12078 unc-73 unc-73 unc-89 unc-89 ani-1 ani-1 unc-104 unc-104 CBG10896 CBG10896 ist-1 ist-1 mtm-1 mtm-1 kin-32 kin-32 bris-1 bris-1 CBG10230 CBG10230 CBG09969 CBG09969 npp-9 npp-9 feh-1 feh-1 ptp-1 ptp-1 uig-1 uig-1 max-1.1 max-1.1 max-1.2 max-1.2 akt-1 akt-1 hmg-4 hmg-4 ced-6 ced-6 CBG09025 CBG09025 frm-2 frm-2 soc-1 soc-1 frm-1 frm-1 dcap-1 dcap-1 CBG08404 CBG08404 pdk-1 pdk-1 dyc-1 dyc-1 tbc-19 tbc-19 obr-3 obr-3 CBG07612 CBG07612 dyn-1 dyn-1 CBG07104 CBG07104 rog-1 rog-1 frm-10 frm-10 mtm-9 mtm-9 plc-4 plc-4 CBG15745 CBG15745 CBG16074 CBG16074 vav-1 vav-1 mig-10 mig-10 viro-2 viro-2 stn-2 stn-2 dkf-2 dkf-2 CBG17293 CBG17293 CBG17295 CBG17295 frm-3 frm-3 hum-4 hum-4 unc-34 unc-34 cnt-2 cnt-2 Cbr-tag-325 Cbr-tag-325 sel-2 sel-2 pac-1 pac-1 rhgf-2 rhgf-2 mrck-1 mrck-1 unc-70 unc-70 Cbr-ubc-15 Cbr-ubc-15 exoc-8 exoc-8 CBG19790 CBG19790 dkf-1 dkf-1 CBG20134 CBG20134 CBG20227 CBG20227 crml-1 crml-1 cnt-1 cnt-1 nfm-1 nfm-1 icln-1 icln-1 tln-1 tln-1 CBG22220 CBG22220 CBG22314 CBG22314 grp-1 grp-1 frm-7 frm-7 sma-1 sma-1 CBG23324 CBG23324 vps-36 vps-36 CBG13515 CBG13515 CBG26441 CBG26441 CBG27527 CBG27527 lin-10 lin-10 unc-31 unc-31 spt-16 spt-16 hum-6 hum-6
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
CBG06982Protein melted homolog; Belongs to the MELT/VEPH family. (867 aa)
num-1Protein CBR-NUM-1. (636 aa)
CBG05563Protein CBG05563. (520 aa)
snx-17Protein CBG05236. (540 aa)
prhg-1Protein CBG05122. (609 aa)
shc-1Protein CBR-SHC-1. (317 aa)
unc-112Protein CBR-UNC-112. (720 aa)
ephx-1Protein CBR-TAG-218. (1258 aa)
exc-5Protein CBR-EXC-5. (859 aa)
stn-1Protein CBR-STN-1. (422 aa)
cnk-1Protein CBR-CNK-1. (808 aa)
mtm-6Protein CBR-MTM-6. (829 aa)
CBG24914Protein CBG24914. (195 aa)
CBG00040Protein CBG00040. (1622 aa)
dab-1Protein CBR-DAB-1. (483 aa)
smk-1Protein CBR-SMK-1. (1124 aa)
tbc-9Protein CBG01761. (1228 aa)
gtf-2h1Protein CBG01668. (526 aa)
rhgf-1Protein CBR-RHGF-1. (1376 aa)
CBG01639Protein CBG01639. (1579 aa)
CBG01565Protein CBG01565. (188 aa)
cgef-1Protein CBR-CGEF-1. (650 aa)
CBG02248Protein CBG02248. (591 aa)
ani-2Protein CBR-ANI-2. (1038 aa)
ran-5Protein CBR-RAN-5. (390 aa)
tbc-2Protein CBG02508. (944 aa)
shc-2Protein CBR-SHC-2. (620 aa)
wdfy-3Protein CBG03484. (3387 aa)
let-502Rho-associated protein kinase let-502; Negatively regulates mel-11 to relieve the inhibition of mlc- 4, allowing contraction of the circumferentially oriented microfilaments in epidermal cells and thereby regulating myosin II contractility during spermathecal contraction, cleavage furrow contraction in early embryos, and embryonic elongation and morphogenesis. Required for P-cell migration. May also play a role in oocyte cellularization (By similarity). (1194 aa)
obr-4Oxysterol-binding protein; Belongs to the OSBP family. (694 aa)
hmg-3FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (689 aa)
pll-1Phosphoinositide phospholipase C. (1083 aa)
CBG15618Protein CBG15618. (460 aa)
tns-1Protein CBR-TAG-163. (938 aa)
mtm-5Protein CBR-MTM-5. (1776 aa)
apl-1Protein CBR-APL-1. (685 aa)
Cbr-tag-52Protein CBR-TAG-52. (631 aa)
CBG14242Protein CBG14242. (298 aa)
gap-1Protein CBR-GAP-1. (1265 aa)
eps-8Protein CBR-EPS-8. (918 aa)
rga-2Protein CBR-RGA-2. (914 aa)
efa-6Protein CBR-EFA-6. (836 aa)
CBG13318Protein CBG13318. (759 aa)
npp-16Protein CBR-NPP-16. (571 aa)
obr-1Oxysterol-binding protein; Belongs to the OSBP family. (762 aa)
CBG12618Protein CBG12618. (625 aa)
CBG03790Protein CBG03790. (973 aa)
erm-1Protein CBR-ERM-1. (563 aa)
frm-4Protein CBR-FRM-4. (706 aa)
tiam-1Protein CBR-CGEF-2. (610 aa)
CBG12078Protein CBG12078. (812 aa)
unc-73Protein CBR-UNC-73. (1618 aa)
unc-89Protein CBR-UNC-89. (6561 aa)
ani-1Protein CBR-ANI-1. (1199 aa)
unc-104Protein CBR-UNC-104; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1699 aa)
CBG10896Protein CBG10896. (384 aa)
ist-1Protein CBR-IST-1. (1258 aa)
mtm-1Protein CBR-MTM-1. (590 aa)
kin-32Protein CBR-KIN-32; Belongs to the protein kinase superfamily. Tyr protein kinase family. (865 aa)
bris-1Protein CBG10729. (621 aa)
CBG10230Protein CBG10230. (713 aa)
CBG09969Protein CBG09969. (568 aa)
npp-9Protein CBR-NPP-9. (859 aa)
feh-1Protein CBR-FEH-1. (723 aa)
ptp-1Tyrosine-protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (1024 aa)
uig-1Protein CBR-UIG-1. (941 aa)
max-1.1Protein CBG09439. (1217 aa)
max-1.2Protein CBR-MAX-1. (1104 aa)
akt-1Non-specific serine/threonine protein kinase. (605 aa)
hmg-4FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (695 aa)
ced-6Protein CBR-CED-6. (490 aa)
CBG09025Protein CBG09025. (934 aa)
frm-2Protein CBR-FRM-2. (590 aa)
soc-1Protein CBR-SOC-1. (510 aa)
frm-1Protein CBR-FRM-1. (6473 aa)
dcap-1Protein CBR-DCAP-1. (340 aa)
CBG08404Protein CBG08404. (166 aa)
pdk-1Protein CBR-PDK-1. (644 aa)
dyc-1Protein CBR-DYC-1. (985 aa)
tbc-19Protein CBG07319. (1412 aa)
obr-3Protein CBR-OBR-3. (797 aa)
CBG07612Protein CBG07612. (740 aa)
dyn-1Protein CBR-DYN-1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (1440 aa)
CBG07104Protein CBG07104. (529 aa)
rog-1Protein CBR-ROG-1. (661 aa)
frm-10Protein CBR-FRM-10. (533 aa)
mtm-9Protein CBR-MTM-9. (569 aa)
plc-4Phosphoinositide phospholipase C. (752 aa)
CBG15745Protein CBG15745. (133 aa)
CBG16074Protein CBG16074. (1209 aa)
vav-1Protein CBR-VAV-1. (971 aa)
mig-10Protein CBR-MIG-10. (739 aa)
viro-2Protein CBG16600. (552 aa)
stn-2Protein CBR-STN-2. (513 aa)
dkf-2Serine/threonine-protein kinase dkf-2; Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Acts in the intestine to regulate both innate immunity by promoting activation of pmk-1 and also stress response and life span by acting as an upstream, negative regulator of the daf-16 transcription factor (By similarity). (1191 aa)
CBG17293Protein CBG17293. (329 aa)
CBG17295Protein CBG17295. (620 aa)
frm-3Protein CBR-FRM-3. (1109 aa)
hum-4Protein CBR-HUM-4; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2720 aa)
unc-34Protein CBR-UNC-34. (459 aa)
cnt-2Protein CBR-CNT-2. (1161 aa)
Cbr-tag-325Protein CBR-TAG-325. (853 aa)
sel-2Putative neurobeachin homolog; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins. Regulates endosomal traffic in polarized epithelial cells such as the vulval precursor cells and intestinal cells. Thought to act as a negative regulator of lin-12 activity in vulval precursor cells. May have a role in the internalization process from basolateral surface of polarized epithelial cells (By similarity). (2531 aa)
pac-1Protein CBG18119. (1623 aa)
rhgf-2Protein CBR-RHGF-2. (919 aa)
mrck-1Protein CBR-MRCK-1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1586 aa)
unc-70Spectrin beta chain; Belongs to the spectrin family. (2370 aa)
Cbr-ubc-15Protein CBR-UBC-15. (578 aa)
exoc-8Protein CBR-EXOC-8. (712 aa)
CBG19790Protein CBG19790. (1099 aa)
dkf-1Serine/threonine-protein kinase dkf-1; Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, independently of PKC. Role in the regulation of growth and neuromuscular control of movement. Involved in immune response to S.aureus bacterium by activating transcription factor hlh-30 downstream of phospholipase plc-1. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily. (760 aa)
CBG20134Protein CBG20134; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (824 aa)
CBG20227Protein CBG20227. (240 aa)
crml-1Protein CBR-CRML-1. (1054 aa)
cnt-1Protein CBR-CNT-1. (824 aa)
nfm-1Protein CBR-NFM-1. (690 aa)
icln-1Protein CBR-ICLN-1. (228 aa)
tln-1Protein CBG22153. (1036 aa)
CBG22220Protein CBG22220. (566 aa)
CBG22314Protein CBG22314. (650 aa)
grp-1Protein CBR-GRP-1. (362 aa)
frm-7Protein CBR-FRM-7. (967 aa)
sma-1Protein CBR-SMA-1. (4156 aa)
CBG23324Protein CBG23324. (408 aa)
vps-36Protein CBR-VPS-36. (383 aa)
CBG13515Protein CBG13515. (589 aa)
CBG26441Protein CBG26441. (111 aa)
CBG27527Protein CBG27527. (428 aa)
lin-10Protein CBR-LIN-10, isoform a. (1120 aa)
unc-31Calcium-dependent secretion activator; Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles. Specifically required to activate the neuronal G-alpha pathway. Functions with G-alpha proteins from the same motor neurons to regulate locomotion. Involved in regulating entry into quiescence triggered by satiety. Probably b [...] (1354 aa)
spt-16FACT complex subunit spt-16; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment [...] (1034 aa)
hum-6Unconventional myosin heavy chain 6; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2099 aa)
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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