(75 nodes) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein network (Necator americanus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	NECAME_14603	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (375 aa)
	NECAME_19204	Uncharacterized protein; Belongs to the peptidase S10 family. (132 aa)
	NECAME_19187	Uncharacterized protein. (91 aa)
	NECAME_19054	Glucosamine 6-phosphate N-acetyltransferase; Belongs to the acetyltransferase family. GNA1 subfamily. (60 aa)
	NECAME_04337	Uncharacterized protein. (178 aa)
	NECAME_13593	GHMP kinase protein. (374 aa)
	NECAME_13592	Fucokinase domain-containing protein. (310 aa)
	NECAME_12925	Phosphomannose isomerase type I. (309 aa)
	NECAME_13474	Glucosamine 6-phosphate N-acetyltransferase; Belongs to the acetyltransferase family. GNA1 subfamily. (212 aa)
	NECAME_04007	Mannose-1-phosphate guanylyltransferase. (354 aa)
	NECAME_00654	PQ loop repeat protein. (244 aa)
	NECAME_16095	Capsule polysaccharide biosynthesis protein. (862 aa)
	NECAME_05853	Phosphoacetylglucosamine mutase; Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O- glycosylation; Belongs to the phosphohexose mutase family. (547 aa)
	NECAME_01373	MSP domain protein. (113 aa)
	NECAME_01357	MSP domain protein. (108 aa)
	NECAME_01372	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. (132 aa)
	NECAME_01358	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. (144 aa)
	NECAME_06550	dTDP-4-dehydrorhamnose 3,5-epimerase. (165 aa)
	NECAME_06588	Carboxypeptidase; Belongs to the peptidase S10 family. (381 aa)
	NECAME_01548	Glycosyltransferase, group 1 family protein. (426 aa)
	NECAME_01482	Uncharacterized protein; Belongs to the peptidase S10 family. (120 aa)
	NECAME_01481	Carboxypeptidase; Belongs to the peptidase S10 family. (701 aa)
	NECAME_06760	Mannosyltransferase. (959 aa)
	NECAME_01484	Serine carboxypeptidase; Belongs to the peptidase S10 family. (671 aa)
	NECAME_06975	GDP-mannose 4,6-dehydratase. (388 aa)
	NECAME_06667	Carboxypeptidase; Belongs to the peptidase S10 family. (468 aa)
	NECAME_06587	Carboxypeptidase; Belongs to the peptidase S10 family. (726 aa)
	NECAME_01480	Serine carboxypeptidase; Belongs to the peptidase S10 family. (350 aa)
	NECAME_06664	Thioredoxin domain-containing protein. (656 aa)
	NECAME_07229	Glycosyltransferase, group 1 family protein. (254 aa)
	NECAME_07339	TPT domain-containing protein. (263 aa)
	NECAME_17235	Uncharacterized protein. (169 aa)
	NECAME_17491	Amidohydro-rel domain-containing protein. (260 aa)
	NECAME_01732	Bacterial transferase hexapeptide repeat protein. (358 aa)
	NECAME_17329	Class II glutamine amidotransferase. (145 aa)
	NECAME_07230	ALG11_N domain-containing protein. (179 aa)
	NECAME_17330	Putative glutamine-fructose-6-phosphate transaminase. (342 aa)
	NECAME_17661	LysR substrate binding domain protein. (307 aa)
	NECAME_17492	Calponin-homology (CH) domain-containing protein. (252 aa)
	NECAME_17817	Uncharacterized protein. (107 aa)
	NECAME_08395	Carboxypeptidase; Belongs to the peptidase S10 family. (319 aa)
	NECAME_08112	MARVEL domain-containing protein. (157 aa)
	NECAME_08397	Carboxypeptidase; Belongs to the peptidase S10 family. (118 aa)
	NECAME_08249	Ribosomal protein L5. (631 aa)
	NECAME_08396	Uncharacterized protein. (125 aa)
	NECAME_09698	Alkyl transferase; Belongs to the UPP synthase family. (338 aa)
	NECAME_10107	Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase. (418 aa)
	NECAME_09906	Uncharacterized protein. (213 aa)
	NECAME_09960	Uncharacterized protein. (154 aa)
	NECAME_09838	MSP domain protein. (109 aa)
	NECAME_09961	Hydrolase, NUDIX family. (200 aa)
	NECAME_18202	SIS domain protein. (171 aa)
	NECAME_18178	Uncharacterized protein. (55 aa)
	NECAME_10843	Uncharacterized protein. (280 aa)
	NECAME_10553	Uncharacterized protein. (95 aa)
	NECAME_10329	Alpha-1,3-glucosyltransferase; Belongs to the ALG6/ALG8 glucosyltransferase family. (380 aa)
	NECAME_18255	Uncharacterized protein. (78 aa)
	NECAME_10496	Mannosyltransferase. (513 aa)
	NECAME_03160	Protein RFT1 homolog; May be involved in N-linked oligosaccharide assembly. Belongs to the RFT1 family. (353 aa)
	NECAME_10552	Glycosyltransferase, group 4 family. (322 aa)
	NECAME_03041	Uncharacterized protein. (174 aa)
	NECAME_11248	UTP--glucose-1-phosphate uridylyltransferase. (245 aa)
	NECAME_11542	Glycosyltransferase, group 1 family protein. (552 aa)
	NECAME_11598	Fucokinase domain-containing protein. (287 aa)
	NECAME_00495	Phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions. (271 aa)
	NECAME_19688	Glycosyltransferase family 28 protein. (213 aa)
	NECAME_03877	Tat pathway signal sequence domain protein. (162 aa)
	NECAME_00590	Mannose-6-phosphate isomerase. (394 aa)
	NECAME_15869	Dolichol-phosphate mannosyltransferase subunit 3; Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER. Belongs to the DPM3 family. (96 aa)
	NECAME_15674	Ubiquitin--protein ligase. (393 aa)
	NECAME_15564	Serine carboxypeptidase; Belongs to the peptidase S10 family. (237 aa)
	NECAME_15565	Serine carboxypeptidase; Belongs to the peptidase S10 family. (196 aa)
	NECAME_15126	Uncharacterized protein. (111 aa)
	NECAME_15566	Carboxypeptidase; Belongs to the peptidase S10 family. (496 aa)
	NECAME_14713	Oligosaccharide biosynthesis protein Alg14 like protein. (192 aa)

Your Current Organism:

Necator americanus

NCBI taxonomy Id: 51031
Other names: N. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NECAME_00495	NECAME_00590	W2T4L4	W2T0U0	Phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions.	Mannose-6-phosphate isomerase.	0.992
NECAME_00495	NECAME_00654	W2T4L4	W2T019	Phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions.	PQ loop repeat protein.	0.539
NECAME_00495	NECAME_01548	W2T4L4	W2TV95	Phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions.	Glycosyltransferase, group 1 family protein.	0.617
NECAME_00495	NECAME_01732	W2T4L4	W2TQI7	Phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions.	Bacterial transferase hexapeptide repeat protein.	0.993
NECAME_00495	NECAME_03041	W2T4L4	W2T8C6	Phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions.	Uncharacterized protein.	0.403
NECAME_00495	NECAME_03877	W2T4L4	W2T1W0	Phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions.	Tat pathway signal sequence domain protein.	0.607
NECAME_00495	NECAME_04007	W2T4L4	W2SZT3	Phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions.	Mannose-1-phosphate guanylyltransferase.	0.993
NECAME_00495	NECAME_05853	W2T4L4	W2TXT3	Phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions.	Phosphoacetylglucosamine mutase; Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O- glycosylation; Belongs to the phosphohexose mutase family.	0.631
NECAME_00495	NECAME_06550	W2T4L4	W2TVS3	Phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions.	dTDP-4-dehydrorhamnose 3,5-epimerase.	0.938
NECAME_00495	NECAME_06664	W2T4L4	W2TS31	Phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions.	Thioredoxin domain-containing protein.	0.617
NECAME_00495	NECAME_07229	W2T4L4	W2TRU0	Phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions.	Glycosyltransferase, group 1 family protein.	0.660
NECAME_00495	NECAME_07230	W2T4L4	W2TPP5	Phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions.	ALG11_N domain-containing protein.	0.660
NECAME_00495	NECAME_08249	W2T4L4	W2TIQ9	Phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions.	Ribosomal protein L5.	0.681
NECAME_00495	NECAME_10329	W2T4L4	W2T921	Phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions.	Alpha-1,3-glucosyltransferase; Belongs to the ALG6/ALG8 glucosyltransferase family.	0.418
NECAME_00495	NECAME_11542	W2T4L4	W2T4V8	Phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions.	Glycosyltransferase, group 1 family protein.	0.756
NECAME_00495	NECAME_12925	W2T4L4	W2SY26	Phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions.	Phosphomannose isomerase type I.	0.992
NECAME_00495	NECAME_16095	W2T4L4	W2U0N3	Phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions.	Capsule polysaccharide biosynthesis protein.	0.617
NECAME_00495	NECAME_17661	W2T4L4	W2TNW8	Phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions.	LysR substrate binding domain protein.	0.616
NECAME_00590	NECAME_00495	W2T0U0	W2T4L4	Mannose-6-phosphate isomerase.	Phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions.	0.992
NECAME_00590	NECAME_01732	W2T0U0	W2TQI7	Mannose-6-phosphate isomerase.	Bacterial transferase hexapeptide repeat protein.	0.621