STRINGSTRING
WNT1 WNT1 WNT10B WNT10B GLI2 GLI2 MYC MYC YAP1 YAP1 Ywhae Ywhae LOC101967743 LOC101967743 WNT2 WNT2 BIRC3 BIRC3 Birc2 Birc2 WNT16 WNT16 WNT6 WNT6 Actg1 Actg1 WNT8A WNT8A ID1 ID1 FZD6 FZD6 WNT9A WNT9A DVL2 DVL2 AREG AREG CRB1 CRB1 PARD6B PARD6B TP53BP2 TP53BP2 PPP1CC PPP1CC TGFB1 TGFB1 ACTL9 ACTL9 SMAD3 SMAD3 PPP2CA PPP2CA SMAD1 SMAD1 SOX2 SOX2 FZD3 FZD3 LRRC1 LRRC1 WNT2B WNT2B AXIN1 AXIN1 WNT5B WNT5B PPP2R2D PPP2R2D BMP7 BMP7 PRKCZ PRKCZ LLGL2 LLGL2 DVL1 DVL1 LATS1 LATS1 FZD1 FZD1 TGFBR1 TGFBR1 YWHAG YWHAG Actb Actb LLGL1 LLGL1 PARD6G PARD6G NF2 NF2 WNT10A WNT10A WNT8B WNT8B WNT9B WNT9B ACTL8 ACTL8 LOC101971713 LOC101971713 SAV1 SAV1 PPP2R2A PPP2R2A I3MZY4_ICTTR I3MZY4_ICTTR FZD5 FZD5 PPP1CB PPP1CB BMP6 BMP6 LOC101954496 LOC101954496 Myo15b Myo15b NKD2 NKD2 SMAD4 SMAD4 RASSF1 RASSF1 ACTRT2 ACTRT2 LIMD1 LIMD1 ACTL7A ACTL7A Ccnd2 Ccnd2 CCN2 CCN2 MYO15A MYO15A FZD10 FZD10 SMAD7 SMAD7 AMH AMH FZD4 FZD4 TCF7 TCF7 LDAH LDAH CTNNB1 CTNNB1 BMPR1A BMPR1A PATJ PATJ PARD3 PARD3 Wwc1 Wwc1 BMPR1B BMPR1B PARD6A PARD6A Ywhaz Ywhaz GDF6 GDF6 TCF7L1 TCF7L1 BMP2 BMP2 GDF7 GDF7 CDH1 CDH1 LEF1 LEF1 ENSSTOP00000032383 ENSSTOP00000032383 FRMD1 FRMD1 AMOT AMOT APC APC ENSSTOP00000031765 ENSSTOP00000031765 Bmp8b Bmp8b TCF7L2 TCF7L2 ENSSTOP00000031475 ENSSTOP00000031475 ENSSTOP00000030884 ENSSTOP00000030884 ENSSTOP00000030810 ENSSTOP00000030810 ENSSTOP00000030497 ENSSTOP00000030497 ENSSTOP00000030397 ENSSTOP00000030397 PPP2R2B PPP2R2B ENSSTOP00000030003 ENSSTOP00000030003 MOB1A MOB1A Ywhaq Ywhaq PPP2R2C PPP2R2C FZD7 FZD7 TEAD3 TEAD3 WWTR1 WWTR1 ENSSTOP00000027631 ENSSTOP00000027631 Ppp2cb Ppp2cb STK3 STK3 APC2 APC2 DLG1 DLG1 ENSSTOP00000027109 ENSSTOP00000027109 ENSSTOP00000027094 ENSSTOP00000027094 LOC101955219 LOC101955219 PPP2R1B PPP2R1B PPP1CA PPP1CA ENSSTOP00000025973 ENSSTOP00000025973 ENSSTOP00000025781 ENSSTOP00000025781 TEAD1 TEAD1 DVL3 DVL3 TGFBR2 TGFBR2 DLG4 DLG4 ENSSTOP00000024550 ENSSTOP00000024550 DLG3 DLG3 LOC101965246 LOC101965246 CCND3 CCND3 CRB2 CRB2 GSK3B GSK3B MOB1B MOB1B TEAD2 TEAD2 NKD1 NKD1 GDF5 GDF5 FZD2 FZD2 FZD8 FZD8 DLG5 DLG5 TP73 TP73 FBXW11 FBXW11 TGFB3 TGFB3 WNT7B WNT7B I3NCC6_ICTTR I3NCC6_ICTTR FZD9 FZD9 WTIP WTIP FGF1 FGF1 ID2 ID2 WNT3A WNT3A BIRC5 BIRC5 BTRC BTRC TEAD4 TEAD4 WNT11 WNT11 LATS2 LATS2 WNT5A WNT5A WNT3 WNT3 SNAI2 SNAI2 AXIN2 AXIN2 YWHAH YWHAH AJUBA AJUBA WNT7A WNT7A ACTL7B ACTL7B ACTRT1 ACTRT1 I3N3K3_ICTTR I3N3K3_ICTTR RASSF6 RASSF6 CCND1 CCND1 SERPINE1 SERPINE1 WNT4 WNT4 CTNNA1 CTNNA1 PPP2R1A PPP2R1A BMP4 BMP4 TGFB2 TGFB2 ITGB2 ITGB2 MPP5 MPP5 CSNK1D CSNK1D BMPR2 BMPR2 BMP5 BMP5 PRKCI PRKCI DLG2 DLG2 FRMD6 FRMD6 AFP AFP SCRIB SCRIB YWHAB YWHAB SMAD2 SMAD2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
GLI2GLI family zinc finger 2. (1540 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (453 aa)
YAP1Yes associated protein 1. (397 aa)
Ywhae14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (255 aa)
LOC101967743Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (416 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
Birc2Uncharacterized protein. (611 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
Actg1Uncharacterized protein. (375 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (151 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (711 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
AREGAmphiregulin. (252 aa)
CRB1Crumbs cell polarity complex component 1. (1406 aa)
PARD6BPar-6 family cell polarity regulator beta. (350 aa)
TP53BP2Tumor protein p53 binding protein 2. (1134 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ACTL9Actin like 9; Belongs to the actin family. (415 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
SOX2SRY-box transcription factor 2. (263 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (392 aa)
AXIN1Axin 1. (869 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (400 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (439 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
PRKCZNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (413 aa)
LLGL2LLGL scribble cell polarity complex component 2. (1024 aa)
DVL1Dishevelled segment polarity protein 1. (696 aa)
LATS1Large tumor suppressor kinase 1. (1131 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (643 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (489 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa)
ActbActin beta. (375 aa)
LLGL1LLGL scribble cell polarity complex component 1. (1045 aa)
PARD6GPar-6 family cell polarity regulator gamma. (383 aa)
NF2Neurofibromin 2. (596 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (373 aa)
ACTL8Actin like 8; Belongs to the actin family. (366 aa)
LOC101971713Uncharacterized protein; Belongs to the actin family. (1238 aa)
SAV1Salvador family WW domain containing protein 1. (335 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
I3MZY4_ICTTRUncharacterized protein. (356 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (318 aa)
BMP6Bone morphogenetic protein 6. (507 aa)
LOC101954496Uncharacterized protein. (346 aa)
Myo15bSH3 domain-containing protein. (234 aa)
NKD2NKD inhibitor of WNT signaling pathway 2. (428 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
RASSF1Ras association domain family member 1. (338 aa)
ACTRT2Actin related protein T2; Belongs to the actin family. (435 aa)
LIMD1LIM domains containing 1. (668 aa)
ACTL7AActin like 7A; Belongs to the actin family. (440 aa)
Ccnd2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (288 aa)
CCN2Cellular communication network factor 2. (348 aa)
MYO15AMyosin XVA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (3517 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
AMHAnti-Mullerian hormone. (545 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
TCF7Transcription factor 7. (302 aa)
LDAHLipid droplet associated hydrolase. (325 aa)
CTNNB1Catenin beta 1. (781 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
PATJPATJ crumbs cell polarity complex component. (1360 aa)
PARD3Par-3 family cell polarity regulator. (1296 aa)
Wwc1Uncharacterized protein. (1106 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
PARD6APar-6 family cell polarity regulator alpha. (345 aa)
YwhazTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (245 aa)
GDF6Growth differentiation factor 6. (460 aa)
TCF7L1Transcription factor 7 like 1. (557 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
GDF7Growth differentiation factor 7. (445 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (885 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
ENSSTOP00000032383Uncharacterized protein. (131 aa)
FRMD1FERM domain containing 1. (545 aa)
AMOTAngiomotin. (1068 aa)
APCAPC regulator of WNT signaling pathway. (2865 aa)
ENSSTOP00000031765Uncharacterized protein. (515 aa)
Bmp8bTGF_BETA_2 domain-containing protein. (252 aa)
TCF7L2Transcription factor 7 like 2. (514 aa)
ENSSTOP00000031475Uncharacterized protein; Belongs to the actin family. (173 aa)
ENSSTOP00000030884TGF_BETA_2 domain-containing protein. (272 aa)
ENSSTOP00000030810Uncharacterized protein. (168 aa)
ENSSTOP00000030497SER_THR_PHOSPHATASE domain-containing protein. (298 aa)
ENSSTOP00000030397Uncharacterized protein; Belongs to the actin family. (148 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
ENSSTOP00000030003Uncharacterized protein. (546 aa)
MOB1AMOB kinase activator 1A. (216 aa)
Ywhaq14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (125 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (451 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (598 aa)
TEAD3Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (469 aa)
WWTR1WW domain containing transcription regulator 1. (434 aa)
ENSSTOP00000027631SER_THR_PHOSPHATASE domain-containing protein. (235 aa)
Ppp2cbSerine/threonine-protein phosphatase. (274 aa)
STK3Serine/threonine kinase 3. (491 aa)
APC2APC regulator of WNT signaling pathway 2. (2114 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (939 aa)
ENSSTOP00000027109Uncharacterized protein. (193 aa)
ENSSTOP0000002709414_3_3 domain-containing protein; Belongs to the 14-3-3 family. (208 aa)
LOC101955219Uncharacterized protein. (612 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (658 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (329 aa)
ENSSTOP0000002597314_3_3 domain-containing protein. (119 aa)
ENSSTOP00000025781Guanylate kinase-like domain-containing protein. (243 aa)
TEAD1TEA domain transcription factor 1. (436 aa)
DVL3Dishevelled segment polarity protein 3. (717 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (767 aa)
ENSSTOP00000024550WW domain-containing protein. (993 aa)
DLG3Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family. (867 aa)
LOC10196524614_3_3 domain-containing protein; Belongs to the 14-3-3 family. (245 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (292 aa)
CRB2Crumbs cell polarity complex component 2. (1288 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
MOB1BMOB kinase activator 1B. (216 aa)
TEAD2TEA domain transcription factor 2. (452 aa)
NKD1NKD inhibitor of WNT signaling pathway 1. (444 aa)
GDF5Growth differentiation factor 5. (495 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (556 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (470 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1920 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (634 aa)
FBXW11F-box and WD repeat domain containing 11. (553 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
I3NCC6_ICTTRUncharacterized protein; Belongs to the actin family. (340 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (552 aa)
WTIPWT1 interacting protein. (328 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
BIRC5Baculoviral IAP repeat containing 5. (142 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
TEAD4Transcriptional enhancer factor TEF-3; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (427 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
LATS2Large tumor suppressor kinase 2. (1060 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
AXIN2Axin 2. (840 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa)
AJUBAAjuba LIM protein. (548 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (336 aa)
ACTL7BActin like 7B; Belongs to the actin family. (418 aa)
ACTRT1Actin related protein T1; Belongs to the actin family. (377 aa)
I3N3K3_ICTTRUncharacterized protein. (81 aa)
RASSF6Ras association domain family member 6. (338 aa)
CCND1Cyclin D1. (250 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (325 aa)
CTNNA1Catenin alpha 1. (906 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
ITGB2Integrin beta. (769 aa)
MPP5Membrane palmitoylated protein 5; Belongs to the MAGUK family. (675 aa)
CSNK1DCasein kinase 1 delta. (389 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (582 aa)
DLG2Discs large MAGUK scaffold protein 2. (870 aa)
FRMD6FERM domain containing 6. (622 aa)
AFPAlpha fetoprotein. (608 aa)
SCRIBScribble planar cell polarity protein. (1546 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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