STRINGSTRING
NOTCH2 NOTCH2 ACVR1 ACVR1 CREBBP CREBBP C20orf27 C20orf27 CDH5 CDH5 JAK2 JAK2 SH2B1 SH2B1 GIPC3 GIPC3 GOT1 GOT1 ITGA8 ITGA8 LOC101967701 LOC101967701 SDCBP SDCBP ENG ENG CITED2 CITED2 TGFB1 TGFB1 SCUBE3 SCUBE3 MSX2 MSX2 ACVRL1 ACVRL1 ACVR1B ACVR1B EP300 EP300 INHBC INHBC BMP4 BMP4 THBS1 THBS1 TGFB2 TGFB2 RNF111 RNF111 MSTN MSTN GDF3 GDF3 BMPR2 BMPR2 BMP5 BMP5 STK11 STK11 LRG1 LRG1 SNW1 SNW1 RBPMS RBPMS SMAD2 SMAD2 ZC3H3 ZC3H3 ADAM17 ADAM17 GPC3 GPC3 BMP10 BMP10 BMP3 BMP3 ILK ILK MYOCD MYOCD NEO1 NEO1 AXIN1 AXIN1 INHA INHA FLCN FLCN BMP7 BMP7 PPARG PPARG NODAL NODAL CSNK2B CSNK2B TGFBR1 TGFBR1 GIPC1 GIPC1 FKBP8 FKBP8 Ing2 Ing2 GIPC2 GIPC2 KCP KCP SYNJ2BP SYNJ2BP FURIN FURIN ACVR2B ACVR2B SLC2A10 SLC2A10 FERMT1 FERMT1 BMPR1A BMPR1A PARP1 PARP1 KDR KDR TWSG1 TWSG1 ZIC2 ZIC2 TGFBR3 TGFBR3 TGFB1I1 TGFB1I1 SMAD4 SMAD4 CCN1 CCN1 ACVR2A ACVR2A PELO PELO BMP6 BMP6 RNF165 RNF165 GDF9 GDF9 GATA6 GATA6 GDF6 GDF6 BMP2 BMP2 GDF7 GDF7 GDF15 GDF15 SULF1 SULF1 INHBB INHBB HES1 HES1 CDKN2B CDKN2B INHBE INHBE ZNF423 ZNF423 HES5 HES5 TGFB3 TGFB3 GDF2 GDF2 GDF5 GDF5 GDF10 GDF10 CRB2 CRB2 LOC101961346 LOC101961346 GDF11 GDF11 Gdf1 Gdf1 Gata4 Gata4 KIAA1324L KIAA1324L UBE2O UBE2O TGFBR2 TGFBR2 RBPJ RBPJ TBX20 TBX20 ZEB2 ZEB2 MEN1 MEN1 ENSSTOP00000028075 ENSSTOP00000028075 KIAA0319 KIAA0319 NPNT NPNT NUP93 NUP93 NUMA1 NUMA1 FBXL15 FBXL15 Inhba Inhba ENSSTOP00000030884 ENSSTOP00000030884 DAB2 DAB2 LOC101954817 LOC101954817 LOC101962293 LOC101962293 Bmp8b Bmp8b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NOTCH2Notch receptor 2. (2364 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
CREBBPCREB binding protein. (2410 aa)
C20orf27Chromosome 20 open reading frame 27. (174 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (784 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
SH2B1SH2B adaptor protein 1. (757 aa)
GIPC3GIPC PDZ domain containing family member 3. (312 aa)
GOT1Aspartate aminotransferase. (413 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1066 aa)
LOC101967701TGF_BETA_2 domain-containing protein. (397 aa)
SDCBPSyndecan binding protein. (298 aa)
ENGEndoglin. (463 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (274 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
SCUBE3Signal peptide, CUB domain and EGF like domain containing 3. (990 aa)
MSX2Msh homeobox 2. (267 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
EP300E1A binding protein p300. (2423 aa)
INHBCInhibin subunit beta C. (352 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
THBS1Thrombospondin 1. (1182 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
RNF111Ring finger protein 111. (984 aa)
MSTNMyostatin. (376 aa)
GDF3Growth differentiation factor 3. (360 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (437 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (354 aa)
SNW1SNW domain containing 1. (554 aa)
RBPMSRNA binding protein, mRNA processing factor. (219 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
ZC3H3Zinc finger CCCH-type containing 3. (958 aa)
ADAM17ADAM metallopeptidase domain 17. (811 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (579 aa)
BMP10Bone morphogenetic protein 10. (422 aa)
BMP3Bone morphogenetic protein 3. (487 aa)
ILKIntegrin linked kinase. (452 aa)
MYOCDMyocardin. (894 aa)
NEO1Neogenin 1. (1440 aa)
AXIN1Axin 1. (869 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (368 aa)
FLCNFolliculin. (579 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
NODALNodal growth differentiation factor. (350 aa)
CSNK2BCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (248 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (489 aa)
GIPC1GIPC PDZ domain containing family member 1. (333 aa)
FKBP8Peptidylprolyl isomerase. (374 aa)
Ing2Inhibitor of growth protein. (280 aa)
GIPC2GIPC PDZ domain containing family member 2. (315 aa)
KCPKielin cysteine rich BMP regulator. (1551 aa)
SYNJ2BPSynaptojanin 2 binding protein. (145 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (794 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (527 aa)
SLC2A10Solute carrier family 2 member 10; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (548 aa)
FERMT1Fermitin family member 1. (596 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1345 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
ZIC2Zic family member 2. (341 aa)
TGFBR3Transforming growth factor beta receptor 3. (851 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (479 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
CCN1Cellular communication network factor 1. (381 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (521 aa)
PELOProtein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa)
BMP6Bone morphogenetic protein 6. (507 aa)
RNF165Ring finger protein 165. (341 aa)
GDF9Growth differentiation factor 9. (449 aa)
GATA6GATA binding protein 6. (593 aa)
GDF6Growth differentiation factor 6. (460 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
GDF7Growth differentiation factor 7. (445 aa)
GDF15Growth differentiation factor 15. (329 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (869 aa)
INHBBInhibin subunit beta B. (336 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (162 aa)
INHBEInhibin subunit beta E. (349 aa)
ZNF423Zinc finger protein 423. (1287 aa)
HES5Hes family bHLH transcription factor 5. (141 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
GDF2Growth differentiation factor 2. (429 aa)
GDF5Growth differentiation factor 5. (495 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (472 aa)
CRB2Crumbs cell polarity complex component 2. (1288 aa)
LOC101961346Left-right determination factor. (363 aa)
GDF11Growth differentiation factor 11. (387 aa)
Gdf1TGF_BETA_2 domain-containing protein. (373 aa)
Gata4GATA-type domain-containing protein. (212 aa)
KIAA1324LKIAA1324 like. (957 aa)
UBE2OUbiquitin conjugating enzyme E2 O. (1249 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (522 aa)
TBX20T-box transcription factor 20. (446 aa)
ZEB2Zinc finger E-box binding homeobox 2. (1249 aa)
MEN1Menin 1. (616 aa)
ENSSTOP00000028075Uncharacterized protein. (77 aa)
KIAA0319KIAA0319. (901 aa)
NPNTNephronectin. (612 aa)
NUP93Nuclear pore complex protein Nup93; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance; Belongs to the nucleoporin interacting component (NIC) family. (819 aa)
NUMA1Nuclear mitotic apparatus protein 1. (2106 aa)
FBXL15F-box and leucine rich repeat protein 15. (310 aa)
InhbaTGF_BETA_2 domain-containing protein. (133 aa)
ENSSTOP00000030884TGF_BETA_2 domain-containing protein. (272 aa)
DAB2DAB adaptor protein 2. (767 aa)
LOC101954817Inhibitor of growth protein 2 pseudogene. (174 aa)
LOC101962293Left-right determination factor. (367 aa)
Bmp8bTGF_BETA_2 domain-containing protein. (252 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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