STRINGSTRING
NOTCH2 NOTCH2 ERBB4 ERBB4 KDM5B KDM5B CCND1 CCND1 RTN4 RTN4 ACVRL1 ACVRL1 Cdc42 Cdc42 HMX2 HMX2 VASH2 VASH2 AGAP2 AGAP2 BMP4 BMP4 CCR2 CCR2 VEGFC VEGFC TGM1 TGM1 BMPR2 BMPR2 BMP5 BMP5 SEMA5A SEMA5A ATP7A ATP7A Itgb3 Itgb3 LRG1 LRG1 EPGN EPGN SAAL1 SAAL1 PRKD1 PRKD1 FGFR2 FGFR2 Xbp1 Xbp1 GRN GRN ADORA2B ADORA2B NKX2-5 NKX2-5 TBX1 TBX1 ADAM17 ADAM17 F3 F3 TWIST2 TWIST2 NR4A3 NR4A3 BTK BTK I3M4W8_ICTTR I3M4W8_ICTTR CCL24 CCL24 DLX5 DLX5 EYA1 EYA1 B4GALT1 B4GALT1 ZNF703 ZNF703 PROK1 PROK1 WNT2 WNT2 RICTOR RICTOR SP1 SP1 CXCL12 CXCL12 GATA2 GATA2 HLX HLX IL10 IL10 EGFR EGFR STAT3 STAT3 ID1 ID1 TNFAIP3 TNFAIP3 ECM1 ECM1 BAD BAD MMP12 MMP12 Azin1 Azin1 VEGFA VEGFA FOXP2 FOXP2 THBS4 THBS4 HTR2B HTR2B CLDN1 CLDN1 ST8SIA1 ST8SIA1 LOC101962660 LOC101962660 ITGA4 ITGA4 MYDGF MYDGF KIF3A KIF3A MAP2K5 MAP2K5 AKT3 AKT3 SRSF6 SRSF6 CYP7B1 CYP7B1 SMO SMO PAX2 PAX2 EMC10 EMC10 PLCG1 PLCG1 STXBP4 STXBP4 TNF TNF NODAL NODAL PDPK1 PDPK1 PKHD1 PKHD1 TGFBR1 TGFBR1 ESRP2 ESRP2 MST1 MST1 TP63 TP63 VHL VHL VEGFB VEGFB ESRP1 ESRP1 GLUL GLUL ODAM ODAM Jaml Jaml OSR1 OSR1 GHSR GHSR CCL5 CCL5 BMPR1A BMPR1A IQGAP3 IQGAP3 CTNNB1 CTNNB1 KDR KDR HYAL1 HYAL1 ZNF580 ZNF580 LOC101965906 LOC101965906 IL18 IL18 SHH SHH SIRT1 SIRT1 AR AR CAV1 CAV1 NR4A1 NR4A1 RREB1 RREB1 Fgf2 Fgf2 MDK MDK I3MV62_ICTTR I3MV62_ICTTR Ccnd2 Ccnd2 I3MVL6_ICTTR I3MVL6_ICTTR FGF7 FGF7 SFRP1 SFRP1 NOD2 NOD2 Egfl7 Egfl7 WDR48 WDR48 AGTR1 AGTR1 C5AR2 C5AR2 HPN HPN BMP6 BMP6 MED1 MED1 I3N090_ICTTR I3N090_ICTTR FGF10 FGF10 EGR3 EGR3 FLT4 FLT4 Znf304 Znf304 LOC101960206 LOC101960206 HSF4 HSF4 DAB2IP DAB2IP BMP2 BMP2 OSR2 OSR2 PDGFB PDGFB I3N4S4_ICTTR I3N4S4_ICTTR BNC1 BNC1 SCG2 SCG2 NRARP NRARP CDH13 CDH13 PGF PGF WNT5A WNT5A SOX9 SOX9 CCR3 CCR3 IHH IHH WNT3A WNT3A PTN PTN JCAD JCAD FGF1 FGF1 JUN JUN GPBAR1 GPBAR1 APLNR APLNR Foxp1 Foxp1 CAV2 CAV2 FGF18 FGF18 Aggf1 Aggf1 Pdcl3 Pdcl3 GDF2 GDF2 TBX18 TBX18 C5AR1 C5AR1 Hmga2 Hmga2 DICER1 DICER1 GHRL GHRL HTRA1 HTRA1 CYBA CYBA TGFA TGFA LOC101968118 LOC101968118 Apela Apela CFLAR CFLAR TWIST1 TWIST1 FOXE3 FOXE3 SIRT6 SIRT6 CCL26 CCL26 HMOX1 HMOX1 PDCD6 PDCD6 FGFR1 FGFR1 NF1 NF1 ITPR1 ITPR1 PROX1 PROX1 APLN APLN AKT1 AKT1 PLXNB3 PLXNB3 NME1 NME1 DYSF DYSF RUNX2 RUNX2 FZD7 FZD7 PPP1R16B PPP1R16B Pik3cd Pik3cd IGF1 IGF1 CDH3 CDH3 SCN5A SCN5A RPTOR RPTOR LOC101966144 LOC101966144 TCF7L2 TCF7L2 MTOR MTOR PRKD2 PRKD2 FGFR3 FGFR3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NOTCH2Notch receptor 2. (2364 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
KDM5BLysine demethylase 5B. (1544 aa)
CCND1Cyclin D1. (250 aa)
RTN4Reticulon. (1177 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
Cdc42Uncharacterized protein. (191 aa)
HMX2H6 family homeobox 2. (273 aa)
VASH2Vasohibin 2. (355 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1116 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
CCR2C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (373 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (417 aa)
TGM1Transglutaminase 1. (812 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
SEMA5ASemaphorin 5A. (1074 aa)
ATP7AATPase copper transporting alpha. (1495 aa)
Itgb3Integrin beta; Belongs to the integrin beta chain family. (792 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (354 aa)
EPGNEpithelial mitogen. (153 aa)
SAAL1Serum amyloid A like 1. (474 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (843 aa)
FGFR2Fibroblast growth factor receptor. (823 aa)
Xbp1BZIP domain-containing protein. (351 aa)
GRNGranulin precursor. (596 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (332 aa)
NKX2-5NK2 homeobox 5. (321 aa)
TBX1T-box transcription factor 1. (406 aa)
ADAM17ADAM metallopeptidase domain 17. (811 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (293 aa)
TWIST2Twist family bHLH transcription factor 2. (160 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (630 aa)
BTKTyrosine-protein kinase. (659 aa)
I3M4W8_ICTTRUncharacterized protein. (207 aa)
CCL24C-C motif chemokine. (119 aa)
DLX5Distal-less homeobox 5. (289 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
B4GALT1Beta-1,4-galactosyltransferase 1. (398 aa)
ZNF703Zinc finger protein 703. (556 aa)
PROK1Prokineticin 1. (96 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1660 aa)
SP1Sp1 transcription factor. (788 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
GATA2GATA binding protein 2. (481 aa)
HLXH2.0 like homeobox. (490 aa)
IL10Interleukin 10. (178 aa)
EGFRReceptor protein-tyrosine kinase. (1192 aa)
STAT3Signal transducer and activator of transcription. (748 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (151 aa)
TNFAIP3TNF alpha induced protein 3. (776 aa)
ECM1Extracellular matrix protein 1. (544 aa)
BADBCL2 associated agonist of cell death. (208 aa)
MMP12Matrix metallopeptidase 12. (477 aa)
Azin1Uncharacterized protein; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (448 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (392 aa)
FOXP2Forkhead box P2. (737 aa)
THBS4Thrombospondin 4. (961 aa)
HTR2B5-hydroxytryptamine receptor 2B. (480 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
ST8SIA1ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (356 aa)
LOC101962660Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (824 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
MYDGFMyeloid derived growth factor. (165 aa)
KIF3AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (726 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
SRSF6Serine and arginine rich splicing factor 6. (342 aa)
CYP7B1Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (497 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
PAX2Paired box 2. (417 aa)
EMC10ER membrane protein complex subunit 10. (223 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
STXBP4Syntaxin binding protein 4. (558 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
NODALNodal growth differentiation factor. (350 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (556 aa)
PKHD1PKHD1 ciliary IPT domain containing fibrocystin/polyductin. (4063 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (489 aa)
ESRP2Epithelial splicing regulatory protein 2. (709 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (715 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
VHLVon Hippel-Lindau tumor suppressor. (182 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (184 aa)
ESRP1Epithelial splicing regulatory protein 1. (682 aa)
GLULGlutamine synthetase. (373 aa)
ODAMOdontogenic, ameloblast associated. (278 aa)
JamlUncharacterized protein. (374 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
CCL5C-C motif chemokine ligand 5. (91 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
IQGAP3IQ motif containing GTPase activating protein 3. (1632 aa)
CTNNB1Catenin beta 1. (781 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1345 aa)
HYAL1Hyaluronidase. (449 aa)
ZNF580Zinc finger protein 580. (172 aa)
LOC101965906Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (970 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
SHHSonic hedgehog signaling molecule. (370 aa)
SIRT1Sirtuin 1. (602 aa)
ARAndrogen receptor. (884 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (598 aa)
RREB1Ras responsive element binding protein 1. (1741 aa)
Fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (144 aa)
MDKMidkine. (143 aa)
I3MV62_ICTTRPhosducin domain-containing protein. (198 aa)
Ccnd2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (288 aa)
I3MVL6_ICTTRUncharacterized protein. (192 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1014 aa)
Egfl7Uncharacterized protein. (146 aa)
WDR48WD repeat domain 48. (677 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (360 aa)
C5AR2Complement component 5a receptor 2. (339 aa)
HPNHepsin; Belongs to the peptidase S1 family. (417 aa)
BMP6Bone morphogenetic protein 6. (507 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1575 aa)
I3N090_ICTTRUncharacterized protein. (207 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
EGR3Early growth response 3. (387 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1363 aa)
Znf304Zinc finger protein 304. (616 aa)
LOC101960206Uncharacterized protein. (207 aa)
HSF4Heat shock transcription factor 4. (491 aa)
DAB2IPDAB2 interacting protein. (1148 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
OSR2Odd-skipped related transciption factor 2. (276 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (211 aa)
I3N4S4_ICTTRUncharacterized protein. (162 aa)
BNC1Basonuclin 1. (960 aa)
SCG2Secretogranin II. (579 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
CDH13Cadherin 13. (613 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
SOX9SRY-box transcription factor 9. (509 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (359 aa)
IHHIndian hedgehog signaling molecule. (379 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
PTNPleiotrophin. (142 aa)
JCADJunctional cadherin 5 associated. (1363 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
GPBAR1G protein-coupled bile acid receptor 1. (331 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
Foxp1Fork-head domain-containing protein. (674 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
Aggf1Uncharacterized protein. (717 aa)
Pdcl3Phosducin domain-containing protein. (240 aa)
GDF2Growth differentiation factor 2. (429 aa)
TBX18T-box transcription factor 18. (614 aa)
C5AR1Complement C5a receptor 1; Belongs to the G-protein coupled receptor 1 family. (356 aa)
Hmga2Uncharacterized protein. (109 aa)
DICER1Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1904 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
HTRA1HtrA serine peptidase 1. (424 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (195 aa)
TGFATransforming growth factor alpha. (159 aa)
LOC101968118Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (932 aa)
ApelaUncharacterized protein. (54 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (488 aa)
TWIST1Twist family bHLH transcription factor 1. (135 aa)
FOXE3Forkhead box E3. (228 aa)
SIRT6Sirtuin 6. (351 aa)
CCL26C-C motif chemokine. (91 aa)
HMOX1Heme oxygenase 1. (288 aa)
PDCD6Programmed cell death 6. (191 aa)
FGFR1Fibroblast growth factor receptor. (822 aa)
NF1Neurofibromin 1. (2473 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2748 aa)
PROX1Prospero homeobox 1. (737 aa)
APLNApelin. (75 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PLXNB3Plexin B3. (1954 aa)
NME1Nucleoside diphosphate kinase. (152 aa)
DYSFDysferlin. (2121 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (520 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (598 aa)
PPP1R16BProtein phosphatase 1 regulatory subunit 16B. (568 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
IGF1Insulin like growth factor 1. (166 aa)
CDH3Cadherin 3; Cadherins are calcium-dependent cell adhesion proteins. (825 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2019 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
LOC101966144Uncharacterized protein. (147 aa)
TCF7L2Transcription factor 7 like 2. (514 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2577 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
FGFR3Fibroblast growth factor receptor. (804 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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