STRINGSTRING
SMAD2 SMAD2 KCP KCP KDR KDR TWSG1 TWSG1 TGFBR3 TGFBR3 SMAD4 SMAD4 CCN1 CCN1 PELO PELO RNF165 RNF165 GATA6 GATA6 SULF1 SULF1 HES1 HES1 ZNF423 ZNF423 HES5 HES5 GDF2 GDF2 GDF5 GDF5 CRB2 CRB2 Gata4 Gata4 KIAA1324L KIAA1324L UBE2O UBE2O RBPJ RBPJ TBX20 TBX20 NUMA1 NUMA1 FBXL15 FBXL15 ACVRL1 ACVRL1 MSX2 MSX2 SCUBE3 SCUBE3 BMP4 BMP4 BMPR2 BMPR2 NOTCH2 NOTCH2 CDH5 CDH5 ENG ENG GPC3 GPC3 ILK ILK NEO1 NEO1 FKBP8 FKBP8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMAD2Mothers against decapentaplegic homolog. (467 aa)
KCPKielin cysteine rich BMP regulator. (1551 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1345 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
TGFBR3Transforming growth factor beta receptor 3. (851 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
CCN1Cellular communication network factor 1. (381 aa)
PELOProtein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa)
RNF165Ring finger protein 165. (341 aa)
GATA6GATA binding protein 6. (593 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (869 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
ZNF423Zinc finger protein 423. (1287 aa)
HES5Hes family bHLH transcription factor 5. (141 aa)
GDF2Growth differentiation factor 2. (429 aa)
GDF5Growth differentiation factor 5. (495 aa)
CRB2Crumbs cell polarity complex component 2. (1288 aa)
Gata4GATA-type domain-containing protein. (212 aa)
KIAA1324LKIAA1324 like. (957 aa)
UBE2OUbiquitin conjugating enzyme E2 O. (1249 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (522 aa)
TBX20T-box transcription factor 20. (446 aa)
NUMA1Nuclear mitotic apparatus protein 1. (2106 aa)
FBXL15F-box and leucine rich repeat protein 15. (310 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
MSX2Msh homeobox 2. (267 aa)
SCUBE3Signal peptide, CUB domain and EGF like domain containing 3. (990 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
NOTCH2Notch receptor 2. (2364 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (784 aa)
ENGEndoglin. (463 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (579 aa)
ILKIntegrin linked kinase. (452 aa)
NEO1Neogenin 1. (1440 aa)
FKBP8Peptidylprolyl isomerase. (374 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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