STRINGSTRING
TGFBR2 TGFBR2 TBX3 TBX3 RBPJ RBPJ BMP7 BMP7 ISL1 ISL1 APLNR APLNR TBX20 TBX20 FGF8 FGF8 NOS3 NOS3 ROBO2 ROBO2 MSX2 MSX2 ACVRL1 ACVRL1 ROBO1 ROBO1 TGFB2 TGFB2 BMP5 BMP5 Mdm4 Mdm4 ACVR1 ACVR1 SNAI1 SNAI1 ENG ENG TBX2 TBX2 HEYL HEYL GATA5 GATA5 TMEM100 TMEM100 Mdm2 Mdm2 CPLANE2 CPLANE2 BMPR1A BMPR1A SMAD4 SMAD4 BMP2 BMP2 SNAI2 SNAI2 SOX9 SOX9 HEY1 HEY1 DCHS1 DCHS1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
TBX3T-box transcription factor 3. (744 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (522 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
ISL1ISL LIM homeobox 1. (349 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
TBX20T-box transcription factor 20. (446 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1228 aa)
ROBO2Roundabout guidance receptor 2. (1468 aa)
MSX2Msh homeobox 2. (267 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
ROBO1Roundabout guidance receptor 1. (1587 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
Mdm4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (490 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
ENGEndoglin. (463 aa)
TBX2T-box transcription factor 2. (712 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (321 aa)
GATA5GATA binding protein 5. (404 aa)
TMEM100Transmembrane protein 100. (134 aa)
Mdm2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (489 aa)
CPLANE2Ciliogenesis and planar polarity effector 2. (258 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
SOX9SRY-box transcription factor 9. (509 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
DCHS1Dachsous cadherin-related 1. (3293 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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