STRINGSTRING
ACVRL1 ACVRL1 VASH2 VASH2 BMP4 BMP4 CCR2 CCR2 VEGFC VEGFC BMPR2 BMPR2 SEMA5A SEMA5A Itgb3 Itgb3 LRG1 LRG1 PRKD1 PRKD1 ADORA2B ADORA2B ADAM17 ADAM17 F3 F3 CCL24 CCL24 PROK1 PROK1 WNT2 WNT2 RICTOR RICTOR SP1 SP1 CXCL12 CXCL12 GATA2 GATA2 IL10 IL10 STAT3 STAT3 ECM1 ECM1 VEGFA VEGFA THBS4 THBS4 HTR2B HTR2B LOC101962660 LOC101962660 ITGA4 ITGA4 MYDGF MYDGF AKT3 AKT3 EMC10 EMC10 PLCG1 PLCG1 PDPK1 PDPK1 TGFBR1 TGFBR1 VEGFB VEGFB GHSR GHSR KDR KDR ZNF580 ZNF580 LOC101965906 LOC101965906 SIRT1 SIRT1 CAV1 CAV1 NR4A1 NR4A1 Fgf2 Fgf2 MDK MDK I3MV62_ICTTR I3MV62_ICTTR FGF7 FGF7 Egfl7 Egfl7 AGTR1 AGTR1 BMP6 BMP6 FGF10 FGF10 EGR3 EGR3 FLT4 FLT4 BMP2 BMP2 PDGFB PDGFB SCG2 SCG2 NRARP NRARP CDH13 CDH13 PGF PGF WNT5A WNT5A CCR3 CCR3 JCAD JCAD JUN JUN APLNR APLNR CAV2 CAV2 Aggf1 Aggf1 Pdcl3 Pdcl3 GDF2 GDF2 DICER1 DICER1 GHRL GHRL CYBA CYBA LOC101968118 LOC101968118 Apela Apela SIRT6 SIRT6 CCL26 CCL26 HMOX1 HMOX1 PDCD6 PDCD6 FGFR1 FGFR1 NF1 NF1 PROX1 PROX1 APLN APLN AKT1 AKT1 PLXNB3 PLXNB3 DYSF DYSF PPP1R16B PPP1R16B Pik3cd Pik3cd IGF1 IGF1 RPTOR RPTOR MTOR MTOR PRKD2 PRKD2 FGFR3 FGFR3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
VASH2Vasohibin 2. (355 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
CCR2C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (373 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (417 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
SEMA5ASemaphorin 5A. (1074 aa)
Itgb3Integrin beta; Belongs to the integrin beta chain family. (792 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (354 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (843 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (332 aa)
ADAM17ADAM metallopeptidase domain 17. (811 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (293 aa)
CCL24C-C motif chemokine. (119 aa)
PROK1Prokineticin 1. (96 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1660 aa)
SP1Sp1 transcription factor. (788 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
GATA2GATA binding protein 2. (481 aa)
IL10Interleukin 10. (178 aa)
STAT3Signal transducer and activator of transcription. (748 aa)
ECM1Extracellular matrix protein 1. (544 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (392 aa)
THBS4Thrombospondin 4. (961 aa)
HTR2B5-hydroxytryptamine receptor 2B. (480 aa)
LOC101962660Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (824 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
MYDGFMyeloid derived growth factor. (165 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
EMC10ER membrane protein complex subunit 10. (223 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (556 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (489 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (184 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1345 aa)
ZNF580Zinc finger protein 580. (172 aa)
LOC101965906Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (970 aa)
SIRT1Sirtuin 1. (602 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (598 aa)
Fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (144 aa)
MDKMidkine. (143 aa)
I3MV62_ICTTRPhosducin domain-containing protein. (198 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
Egfl7Uncharacterized protein. (146 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (360 aa)
BMP6Bone morphogenetic protein 6. (507 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
EGR3Early growth response 3. (387 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1363 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (211 aa)
SCG2Secretogranin II. (579 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
CDH13Cadherin 13. (613 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (359 aa)
JCADJunctional cadherin 5 associated. (1363 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
Aggf1Uncharacterized protein. (717 aa)
Pdcl3Phosducin domain-containing protein. (240 aa)
GDF2Growth differentiation factor 2. (429 aa)
DICER1Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1904 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (195 aa)
LOC101968118Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (932 aa)
ApelaUncharacterized protein. (54 aa)
SIRT6Sirtuin 6. (351 aa)
CCL26C-C motif chemokine. (91 aa)
HMOX1Heme oxygenase 1. (288 aa)
PDCD6Programmed cell death 6. (191 aa)
FGFR1Fibroblast growth factor receptor. (822 aa)
NF1Neurofibromin 1. (2473 aa)
PROX1Prospero homeobox 1. (737 aa)
APLNApelin. (75 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PLXNB3Plexin B3. (1954 aa)
DYSFDysferlin. (2121 aa)
PPP1R16BProtein phosphatase 1 regulatory subunit 16B. (568 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
IGF1Insulin like growth factor 1. (166 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2577 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
FGFR3Fibroblast growth factor receptor. (804 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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