(72 nodes) Double-strand break repair network (Micromonas commoda)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DMC1	DMC1 DNA recombinase; Belongs to the RecA family. (359 aa)
	MICPUN_65355	SMC_N domain-containing protein. (1025 aa)
	RAD	Rad21-like protein. (713 aa)
	MICPUN_78816	Uncharacterized protein; Belongs to the DEAD box helicase family. (790 aa)
	MICPUN_56516	FHA domain-containing protein. (480 aa)
	MICPUN_79105	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (454 aa)
	MICPUN_56343	Endo/exonuclease/phosphatase domain-containing protein. (539 aa)
	MICPUN_56202	Dead box helicase. (1778 aa)
	MICPUN_57354	Uncharacterized protein. (310 aa)
	MICPUN_57387	XRCC2 DNA recombinase. (439 aa)
	MICPUN_57417	Replication protein A subunit; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses. (525 aa)
	MICPUN_97217	DNA_LIGASE_A3 domain-containing protein. (654 aa)
	MICPUN_108045	Uncharacterized protein. (216 aa)
	MICPUN_57630	Uncharacterized protein. (220 aa)
	RAD51A	DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Unwinds duplex DNA. Component of the meiotic recombination pathway. Seems to play a role in mediating chromosome homology search, chromosome pairing and synapsis at early stages and probably chromosome crossing-over at later stages in meiosis. Probably is involved in the repair of meiotic double strand breaks (DBSs) and in homologous recombination; Belongs to the RecA family. RAD51 subfamily. (344 aa)
	MICPUN_57984	Uncharacterized protein. (68 aa)
	MICPUN_105511	Replication protein A subunit; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses. (867 aa)
	MICPUN_58249	DEAD/DEAH box helicase. (1026 aa)
	SPO11	Type II DNA topoisomerase VI subunit A 1. (430 aa)
	MICPUN_58505	Nucleosome/chromatin assembly complex protein. (617 aa)
	MICPUN_69395	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (380 aa)
	MICPUN_50295	Uncharacterized protein. (652 aa)
	MICPUN_58647	Checkpoint protein; Belongs to the HUS1 family. (321 aa)
	MICPUN_100625	Uncharacterized protein. (420 aa)
	MICPUN_108308	DNA_pol_B_thumb domain-containing protein. (194 aa)
	MICPUN_108386	Structure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA; Belongs to the SLX1 family. (420 aa)
	RAD51D	Rad51 DNA recombinase 4. (292 aa)
	MICPUN_59282	BRCT domain-containing protein. (742 aa)
	MICPUN_86424	Uncharacterized protein. (632 aa)
	MICPUN_62505	Nucleosome assembly factor. (224 aa)
	MICPUN_62527	RING-type domain-containing protein. (158 aa)
	MICPUN_95766	DNA helicase; Belongs to the MCM family. (817 aa)
	MICPUN_63823	Uncharacterized protein. (408 aa)
	MICPUN_75058	DNA polymerase. (768 aa)
	MICPUN_87479	Uncharacterized protein. (536 aa)
	MICPUN_103801	POLAc domain-containing protein. (953 aa)
	RAD51B	Rad51 DNA recombinase 2. (440 aa)
	MICPUN_104126	POLAc domain-containing protein. (972 aa)
	MICPUN_104180	DUF1767 domain-containing protein. (554 aa)
	MICPUN_88516	Uncharacterized protein. (291 aa)
	MICPUN_64641	Uncharacterized protein. (268 aa)
	MICPUN_109622	Uncharacterized protein. (367 aa)
	MICPUN_106619	Enkurin domain-containing protein. (295 aa)
	PSF2	DNA replication complex GINS protein psf2, probable. (249 aa)
	RAD51C	Rad51 DNA recombinase 3. (362 aa)
	TOP6A	DNA topoisomerase 6 subunit A; Component of the DNA topoisomerase VI involved in chromatin organization and progression of endoreduplication cycles. Relaxes both positive and negative superturns and exhibits a strong decatenase activity. (391 aa)
	ERCC	Uncharacterized protein. (221 aa)
	MICPUN_51474	Sister chromatid cohesion protein. (574 aa)
	MICPUN_77461	DNA helicase; Belongs to the MCM family. (658 aa)
	Mus81	Ercc4-like protein. (747 aa)
	Rad50	Rad50 DNA repair/recombination protein. (1319 aa)
	MICPUN_55565	Uncharacterized protein. (1659 aa)
	MICPUN_113588	Uncharacterized protein. (1974 aa)
	MICPUN_69866	53EXOc domain-containing protein. (223 aa)
	MICPUN_84536	zf-C2HE domain-containing protein. (219 aa)
	MICPUN_84407	DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (242 aa)
	MICPUN_60892	SAP domain-containing protein. (780 aa)
	RAD54	SNF2 super family. (1126 aa)
	MICPUN_85826	SMC_N domain-containing protein. (1077 aa)
	BRCA2	Uncharacterized protein. (1531 aa)
	MICPUN_62858	Lactamase_B domain-containing protein. (671 aa)
	MICPUN_62832	Uncharacterized protein. (479 aa)
	MICPUN_108476	Nucleosome/chromatin assembly complex protein; Belongs to the nucleosome assembly protein (NAP) family. (392 aa)
	MICPUN_101095	Uncharacterized protein. (250 aa)
	MICPUN_82471	ERCC4 domain-containing protein. (965 aa)
	MICPUN_59626	Helicase ATP-binding domain-containing protein. (1566 aa)
	MICPUN_60057	Ku domain-containing protein. (715 aa)
	MICPUN_60369	Serine/threonine-protein phosphatase. (310 aa)
	MRE11	Mre11 DNA repair/recombination protein. (894 aa)
	MICPUN_66235	Uncharacterized protein. (531 aa)
	XRCC3	XRCC3 DNA recombinase. (382 aa)
	MND1	Meiotic nuclear division protein 1 homolog; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Belongs to the MND1 family. (206 aa)

Your Current Organism:

Micromonas commoda

NCBI taxonomy Id: 296587
Other names: CCMP2709, M. commoda, Micromonas commoda van Baren, Bachy & Worden, 2016, Micromonas pusilla NOUM17, Micromonas pusilla RCC299, Micromonas sp. CCMP1195, Micromonas sp. CCMP1764, Micromonas sp. CCMP492, Micromonas sp. NEPCC29, Micromonas sp. RCC 299, Micromonas sp. RCC299, Micromonas sp. RCC372, Micromonas sp. RCC447, Micromonas sp. RCC448, Micromonas sp. RCC449, Micromonas sp. RCC450, Micromonas sp. RCC472, Micromonas sp. RCC570, Micromonas sp. RCC676, Micromonas sp. RCC803, Micromonas sp. RCC804, Micromonas sp. RCC805, Micromonas sp. RCC808, Micromonas sp. RCC836, RCC299

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRCA2	DMC1	C1FJK2	C1FJ81	Uncharacterized protein.	DMC1 DNA recombinase; Belongs to the RecA family.	0.886
BRCA2	ERCC	C1FJK2	C1FDR2	Uncharacterized protein.	Uncharacterized protein.	0.518
BRCA2	MICPUN_101095	C1FJK2	C1E8R4	Uncharacterized protein.	Uncharacterized protein.	0.405
BRCA2	MICPUN_105511	C1FJK2	C1E508	Uncharacterized protein.	Replication protein A subunit; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses.	0.507
BRCA2	MICPUN_108386	C1FJK2	C1E7L9	Uncharacterized protein.	Structure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA; Belongs to the SLX1 family.	0.578
BRCA2	MICPUN_50295	C1FJK2	C1E6F3	Uncharacterized protein.	Uncharacterized protein.	0.593
BRCA2	MICPUN_56202	C1FJK2	C1E0F8	Uncharacterized protein.	Dead box helicase.	0.502
BRCA2	MICPUN_56516	C1FJK2	C1DZJ4	Uncharacterized protein.	FHA domain-containing protein.	0.789
BRCA2	MICPUN_57387	C1FJK2	C1E2W2	Uncharacterized protein.	XRCC2 DNA recombinase.	0.836
BRCA2	MICPUN_57417	C1FJK2	C1E2Z2	Uncharacterized protein.	Replication protein A subunit; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses.	0.507
BRCA2	MICPUN_57984	C1FJK2	C1E4C1	Uncharacterized protein.	Uncharacterized protein.	0.991
BRCA2	MICPUN_58647	C1FJK2	C1E6F4	Uncharacterized protein.	Checkpoint protein; Belongs to the HUS1 family.	0.444
BRCA2	MICPUN_59626	C1FJK2	C1E971	Uncharacterized protein.	Helicase ATP-binding domain-containing protein.	0.682
BRCA2	MICPUN_60057	C1FJK2	C1EAF7	Uncharacterized protein.	Ku domain-containing protein.	0.514
BRCA2	MICPUN_60892	C1FJK2	C1FGI7	Uncharacterized protein.	SAP domain-containing protein.	0.491
BRCA2	MICPUN_62527	C1FJK2	C1EE76	Uncharacterized protein.	RING-type domain-containing protein.	0.936
BRCA2	MICPUN_62832	C1FJK2	C1FJX3	Uncharacterized protein.	Uncharacterized protein.	0.569
BRCA2	MICPUN_69395	C1FJK2	C1E6B6	Uncharacterized protein.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.593
BRCA2	MICPUN_75058	C1FJK2	C1EFP4	Uncharacterized protein.	DNA polymerase.	0.466
BRCA2	MICPUN_79105	C1FJK2	C1DZV7	Uncharacterized protein.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.593

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