(15 nodes) GRB2 events in ERBB2 signaling network (Seriola lalandi)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	hras	HRas proto-oncogene, GTPase a. (189 aa)
	nrg4	EGF-like domain-containing protein. (109 aa)
	grb2	Growth factor receptor-bound protein 2b. (217 aa)
	LOC111646448	Neuregulin 2b. (696 aa)
	LOC111659601	Neuregulin 1. (642 aa)
	kras	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
	LOC111666218	Neuregulin 2a. (709 aa)
	btc	Betacellulin, epidermal growth factor family member. (187 aa)
	ereg	EGF-like domain-containing protein. (154 aa)
	LOC111649083	Zgc:55558. (187 aa)
	LOC111669639	Neuregulin 3b. (781 aa)
	CSDE1	Cold shock domain containing E1, RNA-binding. (850 aa)
	LOC111652063	Heparin-binding EGF-like growth factor a. (238 aa)
	ENSSLDP00000014257	EGF-like domain-containing protein. (77 aa)
	erbb2	Receptor protein-tyrosine kinase. (1289 aa)

Your Current Organism:

Seriola lalandi

NCBI taxonomy Id: 1841481
Other names: S. lalandi dorsalis, Seriola dorsalis, Seriola lalandi dorsalis

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSDE1	LOC111652063	ENSSLDP00000011164	ENSSLDP00000013564	Cold shock domain containing E1, RNA-binding.	Heparin-binding EGF-like growth factor a.	0.456
CSDE1	btc	ENSSLDP00000011164	ENSSLDP00000008287	Cold shock domain containing E1, RNA-binding.	Betacellulin, epidermal growth factor family member.	0.454
CSDE1	erbb2	ENSSLDP00000011164	ENSSLDP00000023215	Cold shock domain containing E1, RNA-binding.	Receptor protein-tyrosine kinase.	0.538
CSDE1	ereg	ENSSLDP00000011164	ENSSLDP00000005348	Cold shock domain containing E1, RNA-binding.	EGF-like domain-containing protein.	0.434
CSDE1	grb2	ENSSLDP00000011164	ENSSLDP00000031562	Cold shock domain containing E1, RNA-binding.	Growth factor receptor-bound protein 2b.	0.713
ENSSLDP00000014257	LOC111669639	ENSSLDP00000014257	ENSSLDP00000008500	EGF-like domain-containing protein.	Neuregulin 3b.	0.903
LOC111646448	LOC111652063	ENSSLDP00000030122	ENSSLDP00000013564	Neuregulin 2b.	Heparin-binding EGF-like growth factor a.	0.462
LOC111646448	LOC111659601	ENSSLDP00000030122	ENSSLDP00000029998	Neuregulin 2b.	Neuregulin 1.	0.537
LOC111646448	LOC111666218	ENSSLDP00000030122	ENSSLDP00000023470	Neuregulin 2b.	Neuregulin 2a.	0.901
LOC111646448	btc	ENSSLDP00000030122	ENSSLDP00000008287	Neuregulin 2b.	Betacellulin, epidermal growth factor family member.	0.565
LOC111646448	erbb2	ENSSLDP00000030122	ENSSLDP00000023215	Neuregulin 2b.	Receptor protein-tyrosine kinase.	0.701
LOC111646448	ereg	ENSSLDP00000030122	ENSSLDP00000005348	Neuregulin 2b.	EGF-like domain-containing protein.	0.496
LOC111646448	grb2	ENSSLDP00000030122	ENSSLDP00000031562	Neuregulin 2b.	Growth factor receptor-bound protein 2b.	0.550
LOC111646448	nrg4	ENSSLDP00000030122	ENSSLDP00000032497	Neuregulin 2b.	EGF-like domain-containing protein.	0.452
LOC111649083	LOC111652063	ENSSLDP00000008447	ENSSLDP00000013564	Zgc:55558.	Heparin-binding EGF-like growth factor a.	0.456
LOC111649083	btc	ENSSLDP00000008447	ENSSLDP00000008287	Zgc:55558.	Betacellulin, epidermal growth factor family member.	0.454
LOC111649083	erbb2	ENSSLDP00000008447	ENSSLDP00000023215	Zgc:55558.	Receptor protein-tyrosine kinase.	0.538
LOC111649083	ereg	ENSSLDP00000008447	ENSSLDP00000005348	Zgc:55558.	EGF-like domain-containing protein.	0.434
LOC111649083	grb2	ENSSLDP00000008447	ENSSLDP00000031562	Zgc:55558.	Growth factor receptor-bound protein 2b.	0.713
LOC111649083	hras	ENSSLDP00000008447	ENSSLDP00000015907	Zgc:55558.	HRas proto-oncogene, GTPase a.	0.910