(43 nodes) Aldehyde/histidinol dehydrogenase network (Streptomyces rapamycinicus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	AGP52639.1	Succinate-semialdehyde dehdyrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the aldehyde dehydrogenase family. (490 aa)
	AGP51761.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (497 aa)
	AGP51924.1	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the aldehyde dehydrogenase family. (513 aa)
	AGP52066.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the aldehyde dehydrogenase family. (333 aa)
	AGP52319.1	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the aldehyde dehydrogenase family. (509 aa)
	AGP52377.1	Succinate-semialdehyde dehdyrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the aldehyde dehydrogenase family. (492 aa)
	AGP52381.1	Gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the aldehyde dehydrogenase family. (506 aa)
	AGP52776.1	Salicylaldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the aldehyde dehydrogenase family. (486 aa)
	AGP52830.1	Carnitine dehydratase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the aldehyde dehydrogenase family. (495 aa)
	AGP53527.1	Catalyzes the oxidation of acetaldehyde, benzaldehyde, propionaldehyde and other aldehydes; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (507 aa)
	AGP53812.1	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the aldehyde dehydrogenase family. (460 aa)
	AGP53898.1	Betaine-aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the aldehyde dehydrogenase family. (489 aa)
	AGP54103.1	Dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (514 aa)
	AGP54682.1	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (486 aa)
	AGP54692.1	Gamma-aminobutyraldehyde dehydrogenase; Catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the aldehyde dehydrogenase family. (506 aa)
	AGP54697.1	Gamma-aminobutyraldehyde dehydrogenase; Catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the aldehyde dehydrogenase family. (483 aa)
	AGP54793.1	1-pyrroline-5-carboxylate dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (543 aa)
	AGP55732.1	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (488 aa)
	AGP56413.1	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (491 aa)
	AGP56476.1	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (574 aa)
	AGP56875.1	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the aldehyde dehydrogenase family. (485 aa)
	gabD2	NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (536 aa)
	AGP57156.1	Betaine-aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the aldehyde dehydrogenase family. (500 aa)
	AGP57245.1	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (299 aa)
	AGP57246.1	Betaine-aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the aldehyde dehydrogenase family. (486 aa)
	AGP57736.1	Methylmalonate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (498 aa)
	proA	Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (432 aa)
	AGP58225.1	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the aldehyde dehydrogenase family. (488 aa)
	hisD	Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (441 aa)
	AGP58785.1	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (507 aa)
	AGP59031.1	Succinate-semialdehyde dehdyrogenase; In Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (469 aa)
	AGP59221.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (476 aa)
	AGP59228.1	2,5-dioxovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (540 aa)
	AGP59282.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the aldehyde dehydrogenase family. (512 aa)
	AGP59796.1	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (478 aa)
	AGP59894.1	Betaine-aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the aldehyde dehydrogenase family. (495 aa)
	AGP60087.1	Betaine-aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the aldehyde dehydrogenase family. (488 aa)
	AGP60261.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the aldehyde dehydrogenase family. (489 aa)
	AGP60625.1	Gamma-aminobutyraldehyde dehydrogenase; Catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the aldehyde dehydrogenase family. (482 aa)
	AGP60876.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (66 aa)
	AGP61063.1	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (497 aa)
	AGP61398.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the aldehyde dehydrogenase family. (524 aa)
	AGP61404.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the aldehyde dehydrogenase family. (498 aa)

Your Current Organism:

Streptomyces rapamycinicus

NCBI taxonomy Id: 1343740
Other names: S. rapamycinicus NRRL 5491, Streptomyces rapamycinicus NRRL 5491

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGP51761.1	AGP54793.1	M271_00610	M271_16130	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	1-pyrroline-5-carboxylate dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.830
AGP51761.1	AGP57245.1	M271_00610	M271_28955	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.753
AGP51761.1	AGP57736.1	M271_00610	M271_31540	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Methylmalonate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.920
AGP51924.1	AGP57245.1	M271_01435	M271_28955	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the aldehyde dehydrogenase family.	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.814
AGP52066.1	AGP57245.1	M271_02155	M271_28955	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the aldehyde dehydrogenase family.	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.753
AGP52319.1	AGP54793.1	M271_03445	M271_16130	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the aldehyde dehydrogenase family.	1-pyrroline-5-carboxylate dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.836
AGP52319.1	AGP57736.1	M271_03445	M271_31540	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the aldehyde dehydrogenase family.	Methylmalonate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.904
AGP52377.1	AGP52381.1	M271_03735	M271_03755	Succinate-semialdehyde dehdyrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the aldehyde dehydrogenase family.	Gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the aldehyde dehydrogenase family.	0.454
AGP52377.1	AGP57245.1	M271_03735	M271_28955	Succinate-semialdehyde dehdyrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the aldehyde dehydrogenase family.	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.742
AGP52381.1	AGP52377.1	M271_03755	M271_03735	Gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the aldehyde dehydrogenase family.	Succinate-semialdehyde dehdyrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the aldehyde dehydrogenase family.	0.454
AGP52381.1	AGP54793.1	M271_03755	M271_16130	Gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the aldehyde dehydrogenase family.	1-pyrroline-5-carboxylate dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.819
AGP52381.1	AGP57245.1	M271_03755	M271_28955	Gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the aldehyde dehydrogenase family.	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.815
AGP52639.1	AGP57245.1	M271_05060	M271_28955	Succinate-semialdehyde dehdyrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the aldehyde dehydrogenase family.	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.774
AGP52776.1	AGP57245.1	M271_05750	M271_28955	Salicylaldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the aldehyde dehydrogenase family.	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.799
AGP53527.1	AGP57245.1	M271_09570	M271_28955	Catalyzes the oxidation of acetaldehyde, benzaldehyde, propionaldehyde and other aldehydes; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.694
AGP53812.1	AGP57245.1	M271_11055	M271_28955	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the aldehyde dehydrogenase family.	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.833
AGP54682.1	AGP57245.1	M271_15530	M271_28955	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.661
AGP54697.1	AGP57245.1	M271_15610	M271_28955	Gamma-aminobutyraldehyde dehydrogenase; Catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the aldehyde dehydrogenase family.	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.782
AGP54793.1	AGP51761.1	M271_16130	M271_00610	1-pyrroline-5-carboxylate dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.830
AGP54793.1	AGP52319.1	M271_16130	M271_03445	1-pyrroline-5-carboxylate dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the aldehyde dehydrogenase family.	0.836