STRINGSTRING
AOR25213.1 AOR25213.1 serC serC AOR25225.1 AOR25225.1 aroQ aroQ AOR25266.1 AOR25266.1 dapB dapB AOR25326.1 AOR25326.1 AOR25330.1 AOR25330.1 AOR25360.1 AOR25360.1 lysA lysA AOR25380.1 AOR25380.1 dapA dapA dapF dapF AOR25513.1 AOR25513.1 AOR25516.1 AOR25516.1 AOR25540.1 AOR25540.1 AOR25566.1 AOR25566.1 AOR25577.1 AOR25577.1 AOR25578.1 AOR25578.1 tpiA tpiA AOR25724.1 AOR25724.1 AOR25765.1 AOR25765.1 AOR25766.1 AOR25766.1 aroK aroK AOR25776.1 AOR25776.1 AOR25795.1 AOR25795.1 AOR25796.1 AOR25796.1 trpD trpD trpC trpC trpF trpF trpB trpB trpA trpA AOR25823.1 AOR25823.1 AOR25831.1 AOR25831.1 gpmI gpmI AOR25870.1 AOR25870.1 AOR25877.1 AOR25877.1 AOR25883.1 AOR25883.1 AOR25928.1 AOR25928.1 eno eno AOR25990.1 AOR25990.1 AOR26000.1 AOR26000.1 AOR26002.1 AOR26002.1 AOR26011.1 AOR26011.1 aroA aroA AOR26106.1 AOR26106.1 AOR26107.1 AOR26107.1 AOR26108.1 AOR26108.1 AOR26109.1 AOR26109.1 metK metK AOR26144.1 AOR26144.1 AOR26145.1 AOR26145.1 argB argB AOR26148.1 AOR26148.1 proC proC argC argC AOR26152.1 AOR26152.1 AOR26272.1 AOR26272.1 AOR26314.1 AOR26314.1 asd asd AOR26341.1 AOR26341.1 AOR26349.1 AOR26349.1 pgk pgk leuB leuB leuD leuD leuC leuC AOR26608.1 AOR26608.1 AOR26612.1 AOR26612.1 AOR26725.1 AOR26725.1 AOR26726.1 AOR26726.1 pfkA pfkA AOR26774.1 AOR26774.1 aroC aroC AOR26805.1 AOR26805.1 AOR26807.1 AOR26807.1 AOR27012.1 AOR27012.1 thrB thrB AOR27014.1 AOR27014.1 glyA glyA tal tal hisG hisG hisD hisD hisC hisC hisB hisB hisH hisH hisA hisA hisF hisF hisI hisI ilvA ilvA AOR27043.1 AOR27043.1 AOR27044.1 AOR27044.1 AOR27045.1 AOR27045.1 ilvD ilvD
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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AOR25213.13-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (355 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (359 aa)
AOR25225.13-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (316 aa)
aroQ3-dehydroquinate dehydratase II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (138 aa)
AOR25266.1Cystathionine gamma-lyase. (385 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (234 aa)
AOR25326.1Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (396 aa)
AOR25330.1Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (242 aa)
AOR25360.12,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (271 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (430 aa)
AOR25380.1Alanine dehydrogenase. (401 aa)
dapA4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (285 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (266 aa)
AOR25513.1Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (482 aa)
AOR25516.1Isocitrate dehydrogenase; Belongs to the monomeric-type IDH family. (717 aa)
AOR25540.1Cystathionine beta-synthase. (331 aa)
AOR25566.1Branched-chain amino acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (350 aa)
AOR25577.1Glutamine synthetase type III, GlnN. (728 aa)
AOR25578.1Glutamine synthetase type II. (338 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (249 aa)
AOR25724.1Asparagine synthetase B. (554 aa)
AOR25765.1Transketolase, N-terminal section. (280 aa)
AOR25766.1Transketolase, C-terminal section. (317 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (176 aa)
AOR25776.1Aconitate hydratase. (754 aa)
AOR25795.1Anthranilate synthase, aminase component. (432 aa)
AOR25796.1Anthranilate synthase, amidotransferase component. (188 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (328 aa)
trpCIndole-3-glycerol phosphate synthase; Belongs to the TrpC family. (261 aa)
trpFN-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (197 aa)
trpBTryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (393 aa)
trpATryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (254 aa)
AOR25823.1Aspartate aminotransferase. (398 aa)
AOR25831.1Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (329 aa)
gpmI2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (505 aa)
AOR25870.1Aspartate aminotransferase. (385 aa)
AOR25877.1Fructose-bisphosphate aldolase class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (355 aa)
AOR25883.1Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (219 aa)
AOR25928.1Citrate synthase; Belongs to the citrate synthase family. (427 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (429 aa)
AOR25990.1Branched-chain amino acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (320 aa)
AOR26000.1Aspartate kinase; Belongs to the aspartokinase family. (416 aa)
AOR26002.1D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (314 aa)
AOR26011.1Ribose-phosphate pyrophosphokinase. (313 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (406 aa)
AOR26106.12-keto-3-deoxy-D-arabino-heptulosonate-7- phosphate synthase I beta. (360 aa)
AOR26107.1Prephenate dehydrogenase. (283 aa)
AOR26108.1Aminotransferase. (381 aa)
AOR26109.1Prephenate dehydratase. (273 aa)
metKS-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (418 aa)
AOR26144.1Argininosuccinate lyase. (426 aa)
AOR26145.1Acetylornithine deacetylase. (355 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (259 aa)
AOR26148.1Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (374 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (266 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (325 aa)
AOR26152.1Argininosuccinate synthase. (398 aa)
AOR26272.1Cystathionine gamma-synthase. (381 aa)
AOR26314.1Pyruvate kinase; Belongs to the pyruvate kinase family. (478 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (332 aa)
AOR26341.1Phenylalanine 4-monooxygenase. (579 aa)
AOR26349.1Ribose 5-phosphate isomerase. (143 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (396 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (372 aa)
leuD3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (198 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (460 aa)
AOR26608.12-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (389 aa)
AOR26612.1Aspartate kinase; Belongs to the AB hydrolase superfamily. MetX family. (332 aa)
AOR26725.1Glutamate synthase [NADPH] large chain. (1499 aa)
AOR26726.1Glutamate synthase [NADPH] small chain. (488 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (328 aa)
AOR26774.1Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (333 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (354 aa)
AOR26805.1L-allo-threonine aldolase. (339 aa)
AOR26807.1Cystathionine beta-synthase. (348 aa)
AOR27012.1Threonine synthase. (431 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (306 aa)
AOR27014.1Aspartate kinase. (816 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (438 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (217 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (285 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (430 aa)
hisCHistidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (344 aa)
hisBHistidinol-phosphatase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. (377 aa)
hisHImidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (193 aa)
hisA1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (238 aa)
hisFImidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (251 aa)
hisIphosphoribosyl-AMP cyclohydrolase; In the N-terminal section; belongs to the PRA-CH family. (196 aa)
ilvAThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (421 aa)
AOR27043.1Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (493 aa)
AOR27044.1Acetohydroxyacid synthase small subunit. (176 aa)
AOR27045.1Acetolactate synthase large subunit. (577 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (559 aa)
Your Current Organism:
Formosa sp. Hel3A148
NCBI taxonomy Id: 1336795
Other names: F. sp. Hel3_A1_48, Formosa sp. Hel3_A1_48
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