STRINGSTRING
KXU13720.1 KXU13720.1 rpmC rpmC KXU13722.1 KXU13722.1 KXU13697.1 KXU13697.1 KXU13522.1 KXU13522.1 rplGA rplGA KXU13353.1 KXU13353.1 KXU13354.1 KXU13354.1 KXU13355.1 KXU13355.1 KXU13356.1 KXU13356.1 rpmA rpmA rplU rplU rpmI rpmI rplJ rplJ rplL rplL rpmF rpmF rpmGA rpmGA KXU11821.1 KXU11821.1 rpsU rpsU rpsT rpsT rpsC rpsC rpsS rpsS rplB rplB rplW rplW rplC rplC rpsJ rpsJ KXU16510.1 KXU16510.1 KXU16491.1 KXU16491.1 KXU16407.1 KXU16407.1 dnaB dnaB raiA raiA rpsB rpsB recF recF smc smc RadC RadC KXU16229.1 KXU16229.1 KXU16181.1 KXU16181.1 KXU16184.1 KXU16184.1 KXU16150.1 KXU16150.1 dtd dtd rplN rplN rplE rplE rpsZ rpsZ rpsH rpsH rplR rplR rpsE rpsE rpmD rpmD rplO rplO rpsK rpsK rplQ rplQ KXU16558.1 KXU16558.1 rpmB rpmB rpsG rpsG KXU16627.1 KXU16627.1 rplM rplM rpsI rpsI KXU16720.1 KXU16720.1 priA priA rpsQ rpsQ rpsO rpsO KXU16080.1 KXU16080.1 recR recR cshA cshA trxA trxA KXU15966.1 KXU15966.1 dnaI dnaI KXU15922.1 KXU15922.1 cshB cshB gyrB gyrB pdxS pdxS rpsR rpsR rpsF rpsF cutC cutC topA topA udk udk hlpA hlpA rpsA_2 rpsA_2 parE parE KXU15471.1 KXU15471.1 dgkA dgkA KXU15427.1 KXU15427.1 ribD ribD KXU15358.1 KXU15358.1 rplA rplA rplK rplK dnaG dnaG KXU15110.1 KXU15110.1 KXU14793.1 KXU14793.1 recO recO rpsP rpsP RpsP RpsP KXU14241.1 KXU14241.1 rpmH rpmH rnmV rnmV ackA ackA KXU14082.1 KXU14082.1 rpmE2 rpmE2 KXU13728.1 KXU13728.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KXU13720.1Deoxyguanosinetriphosphate triphosphohydrolase. (435 aa)
rpmCLSU ribosomal protein L29p (L35e); Belongs to the universal ribosomal protein uL29 family. (68 aa)
KXU13722.1ATP-dependent RNA helicase YfmL. (107 aa)
KXU13697.1Hypothetical protein. (241 aa)
KXU13522.1Chromosome (plasmid) partitioning protein ParB / Stage 0 sporulation protein J; Belongs to the ParB family. (252 aa)
rplGARibosomal protein L7Ae family protein. (99 aa)
KXU13353.1Replicative DNA helicase (DnaB). (59 aa)
KXU13354.1Replicative DNA helicase (DnaB). (135 aa)
KXU13355.1Phage replication initiation protein. (245 aa)
KXU13356.1Helicase loader DnaI. (273 aa)
rpmALSU ribosomal protein L27p; Belongs to the bacterial ribosomal protein bL27 family. (97 aa)
rplULSU ribosomal protein L21p; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (104 aa)
rpmILSU ribosomal protein L35p; Belongs to the bacterial ribosomal protein bL35 family. (66 aa)
rplJLSU ribosomal protein L10p (P0); Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (166 aa)
rplLLSU ribosomal protein L7/L12 (P1/P2); Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (122 aa)
rpmFLSU ribosomal protein L32p, zinc-independent; Belongs to the bacterial ribosomal protein bL32 family. (60 aa)
rpmGALSU ribosomal protein L33p, zinc-independent; Belongs to the bacterial ribosomal protein bL33 family. (49 aa)
KXU11821.1Chromosome segregation helicase. (126 aa)
rpsUSSU ribosomal protein S21p; Belongs to the bacterial ribosomal protein bS21 family. (58 aa)
rpsTSSU ribosomal protein S20p; Binds directly to 16S ribosomal RNA. (77 aa)
rpsCSSU ribosomal protein S3p (S3e); Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (217 aa)
rpsSSSU ribosomal protein S19p (S15e); Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (93 aa)
rplBLSU ribosomal protein L2p (L8e); One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (277 aa)
rplWLSU ribosomal protein L23p (L23Ae); One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (98 aa)
rplCLSU ribosomal protein L3p (L3e); One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (208 aa)
rpsJSSU ribosomal protein S10p (S20e); Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa)
KXU16510.1Hypothetical protein. (208 aa)
KXU16491.1Hypothetical protein. (115 aa)
KXU16407.1tRNA dihydrouridine synthase B; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (326 aa)
dnaBReplicative DNA helicase (DnaB); Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (255 aa)
raiARibosomal subunit interface protein; Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth. (180 aa)
rpsBSSU ribosomal protein S2p (SAe); Belongs to the universal ribosomal protein uS2 family. (259 aa)
recFDNA recombination and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. (362 aa)
smcChromosome partition protein smc; Required for chromosome condensation and partitioning. Belongs to the SMC family. (653 aa)
RadCDNA repair protein RadC; Belongs to the UPF0758 family. (226 aa)
KXU16229.1Hypothetical protein. (567 aa)
KXU16181.1Helicase loader DnaI. (270 aa)
KXU16184.1Replication protein. (272 aa)
KXU16150.1Two-component system histidine kinase. (300 aa)
dtdD-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (147 aa)
rplNLSU ribosomal protein L14p (L23e); Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa)
rplELSU ribosomal protein L5p (L11e); This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (180 aa)
rpsZSSU ribosomal protein S14p (S29e), zinc-dependent; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. (61 aa)
rpsHSSU ribosomal protein S8p (S15Ae); One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (132 aa)
rplRLSU ribosomal protein L18p (L5e); This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (118 aa)
rpsESSU ribosomal protein S5p (S2e); Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. (164 aa)
rpmDLSU ribosomal protein L30p (L7e). (60 aa)
rplOLSU ribosomal protein L15p (L27Ae); Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (146 aa)
rpsKSSU ribosomal protein S11p (S14e); Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (127 aa)
rplQLSU ribosomal protein L17p. (128 aa)
KXU16558.1Fumarate reductase flavoprotein subunit. (305 aa)
rpmBLSU ribosomal protein L28p; Belongs to the bacterial ribosomal protein bL28 family. (62 aa)
rpsGSSU ribosomal protein S7p (S5e); One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa)
KXU16627.1dTDP-glucose 4,6-dehydratase. (356 aa)
rplMLSU ribosomal protein L13p (L13Ae); This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (148 aa)
rpsISSU ribosomal protein S9p (S16e); Belongs to the universal ribosomal protein uS9 family. (130 aa)
KXU16720.1Hypothetical protein. (375 aa)
priAHelicase PriA; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (795 aa)
rpsQSSU ribosomal protein S17p (S11e); One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (86 aa)
rpsOSSU ribosomal protein S15p (S13e); Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. (89 aa)
KXU16080.1Hypothetical protein; Contains S4-like RNA binding domain. (263 aa)
recRRecombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (198 aa)
cshACold-shock DEAD-box protein A; DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA-dependent ATPase activity; Belongs to the DEAD box helicase family. CshA subfamily. (518 aa)
trxAThioredoxin; Belongs to the thioredoxin family. (107 aa)
KXU15966.1Helicase loader DnaB. (387 aa)
dnaIHelicase loader DnaI. (298 aa)
KXU15922.1General stress protein 13. (120 aa)
cshBATP-dependent RNA helicase YqfR; Probable DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures. (447 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (278 aa)
pdxSPyridoxine biosynthesis glutamine amidotransferase, synthase subunit; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (291 aa)
rpsRSSU ribosomal protein S18p, zinc-independent; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (79 aa)
rpsFSSU ribosomal protein S6p; Binds together with S18 to 16S ribosomal RNA. (96 aa)
cutCCytoplasmic copper homeostasis protein cutC; Participates in the control of copper homeostasis. Belongs to the CutC family. (210 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (695 aa)
udkUridine kinase (C1). (212 aa)
hlpADNA-binding protein HBsu; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (91 aa)
rpsA_2SSU ribosomal protein S1p. (400 aa)
parETopoisomerase IV subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 2 subfamily. (647 aa)
KXU15471.1Hypothetical protein. (369 aa)
dgkADiacylglycerol kinase. (131 aa)
KXU15427.1SWF/SNF family helicase. (718 aa)
ribDdCMP deaminase / Late competence protein ComEB. (155 aa)
KXU15358.1Chromosome replication initiation protein dnaD. (225 aa)
rplALSU ribosomal protein L1p (L10Ae); Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (229 aa)
rplKLSU ribosomal protein L11p (L12e); Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (141 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (586 aa)
KXU15110.1Periplasmic component of efflux system; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (394 aa)
KXU14793.1Transcriptional regulatory protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (99 aa)
recODNA recombination and repair protein RecO; Involved in DNA repair and RecF pathway recombination. (256 aa)
rpsPSSU ribosomal protein S16p; Belongs to the bacterial ribosomal protein bS16 family. (48 aa)
RpsPSSU ribosomal protein S16p. (40 aa)
KXU14241.1Hypothetical protein. (246 aa)
rpmHLSU ribosomal protein L34p; Belongs to the bacterial ribosomal protein bL34 family. (44 aa)
rnmVRibonuclease M5; Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step. (186 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (396 aa)
KXU14082.1L-ribulose-5-phosphate 4-epimerase. (232 aa)
rpmE2LSU ribosomal protein L31p, zinc-independent. (80 aa)
KXU13728.13'-to-5' oligoribonuclease A; Bacillus type. (314 aa)
Your Current Organism:
Streptococcus oralis
NCBI taxonomy Id: 1303
Other names: ATCC 35037, CCUG 13229, CCUG 24891, CIP 102922, DSM 20627, JCM 12997, LMG 14532, LMG:14532, NCTC 11427, S. oralis, strain LVG 1, strain PB 182, strain SK23
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