(88 nodes) Mixed, incl. Autophagy, and Amino acids regulate mTORC1 network (Pestalotiopsis fici)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PFICI_15392	Aspartyl aminopeptidase; Belongs to the peptidase M18 family. (495 aa)
	PFICI_14579	WD_REPEATS_REGION domain-containing protein. (436 aa)
	PFICI_14631	HRDC domain-containing protein. (810 aa)
	PFICI_13791	Uncharacterized protein. (387 aa)
	PFICI_14824	ANK_REP_REGION domain-containing protein. (301 aa)
	PFICI_14166	Uncharacterized protein. (537 aa)
	PFICI_14296	Autophagy-related protein 13; Belongs to the ATG13 family. Fungi subfamily. (941 aa)
	PFICI_14384	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2436 aa)
	PFICI_13137	AMPK1_CBM domain-containing protein. (527 aa)
	PFICI_13883	WD_REPEATS_REGION domain-containing protein. (1473 aa)
	PFICI_13933	C2H2-type domain-containing protein. (738 aa)
	PFICI_13399	Uncharacterized protein. (226 aa)
	PFICI_14073	Atg29_N domain-containing protein. (404 aa)
	PFICI_13398	Non-specific serine/threonine protein kinase. (740 aa)
	PFICI_13579	WD_REPEATS_REGION domain-containing protein. (1362 aa)
	PFICI_13578	Uncharacterized protein. (604 aa)
	PFICI_13723	Uncharacterized protein. (484 aa)
	PFICI_13325	Zn(2)-C6 fungal-type domain-containing protein. (881 aa)
	PFICI_11767	Uncharacterized protein. (1122 aa)
	PFICI_11797	Serine/threonine-protein kinase ATG1. (957 aa)
	PFICI_11836	Uncharacterized protein. (413 aa)
	PFICI_11861	BTB domain-containing protein. (388 aa)
	PFICI_12075	Protein kinase domain-containing protein. (912 aa)
	PFICI_12092	GTP-binding protein rhb1. (187 aa)
	PFICI_12102	WAPL domain-containing protein. (865 aa)
	PFICI_13000	GTP-binding protein gtr2. (396 aa)
	PFICI_11733	Uncharacterized protein. (812 aa)
	PFICI_12074	Protein kinase domain-containing protein. (927 aa)
	PFICI_11833	BTB domain-containing protein. (419 aa)
	PFICI_09837	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. (148 aa)
	PFICI_09901	Uncharacterized protein. (670 aa)
	PFICI_10940	AMPKBI domain-containing protein. (489 aa)
	PFICI_10084	Uncharacterized protein. (140 aa)
	PFICI_10254	Non-specific serine/threonine protein kinase. (1048 aa)
	PFICI_08872	Uncharacterized protein. (131 aa)
	PFICI_09297	Protein kinase domain-containing protein. (1239 aa)
	PFICI_09596	Uncharacterized protein; Belongs to the peptidase M18 family. (523 aa)
	PFICI_07837	Peptidase_S24 domain-containing protein. (170 aa)
	PFICI_07839	Nuclear protein SNF4. (375 aa)
	PFICI_07973	Uncharacterized protein. (508 aa)
	PFICI_08107	Protein kinase domain-containing protein. (699 aa)
	PFICI_08109	Autophagy protein 16. (204 aa)
	PFICI_08103	Uncharacterized protein. (214 aa)
	PFICI_08267	Zinc_ribbon_16 domain-containing protein. (1038 aa)
	PFICI_08444	Autophagy-related protein. (119 aa)
	PFICI_08438	Uncharacterized protein. (968 aa)
	PFICI_06082	Uncharacterized protein. (536 aa)
	PFICI_07840	Rho-GAP domain-containing protein. (1318 aa)
	PFICI_08091	Rap-GAP domain-containing protein. (1627 aa)
	PFICI_06881	Uncharacterized protein. (864 aa)
	PFICI_06349	Uncharacterized protein. (253 aa)
	PFICI_06379	Uncharacterized protein. (2079 aa)
	PFICI_07091	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy wh [...] (708 aa)
	PFICI_07121	Autophagy protein 5; Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. (266 aa)
	PFICI_07255	Uncharacterized protein. (430 aa)
	PFICI_07290	Target of rapamycin complex subunit LST8. (435 aa)
	PFICI_06644	Uncharacterized protein. (482 aa)
	PFICI_04586	Uncharacterized protein. (994 aa)
	PFICI_07169	Uncharacterized protein. (499 aa)
	PFICI_04770	DEP domain-containing protein. (1867 aa)
	PFICI_07319	Autophagy-related protein 18. (430 aa)
	PFICI_05376	Non-specific serine/threonine protein kinase. (638 aa)
	PFICI_05469	Uncharacterized protein. (1569 aa)
	PFICI_05023	Uncharacterized protein. (112 aa)
	PFICI_05328	Uncharacterized protein. (1326 aa)
	PFICI_02998	Phosphatidylinositol 3-kinase VPS34. (912 aa)
	PFICI_03018	WD_REPEATS_REGION domain-containing protein. (1489 aa)
	PFICI_03110	NACHT domain-containing protein. (1007 aa)
	PFICI_03310	UDENN FLCN/SMCR8-type domain-containing protein. (537 aa)
	PFICI_03495	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. (464 aa)
	PFICI_03555	Uncharacterized protein. (478 aa)
	PFICI_03529	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (921 aa)
	PFICI_03575	Uncharacterized protein. (272 aa)
	PFICI_02906	Autophagy-related protein 3. (347 aa)
	PFICI_03126	Uncharacterized protein. (508 aa)
	PFICI_04190	Uncharacterized protein. (357 aa)
	PFICI_00248	Uncharacterized protein. (357 aa)
	PFICI_03956	Sterol 3-beta-glucosyltransferase. (1478 aa)
	PFICI_00543	Non-specific serine/threonine protein kinase. (886 aa)
	PFICI_00743	ATG11 domain-containing protein. (1470 aa)
	PFICI_01101	Telomere_reg-2 domain-containing protein. (970 aa)
	PFICI_00419	Alpha-mann_mid domain-containing protein. (1084 aa)
	PFICI_00614	Autophagy_act_C domain-containing protein. (243 aa)
	PFICI_01636	Autophagy-related protein; Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation; Belongs to the ATG22 family. (652 aa)
	PFICI_01678	Protein kinase domain-containing protein. (871 aa)
	PFICI_01866	SWIM-type domain-containing protein. (456 aa)
	PFICI_01892	DUF1752 domain-containing protein. (585 aa)
	PFICI_01953	Uncharacterized protein. (816 aa)

Your Current Organism:

Pestalotiopsis fici

NCBI taxonomy Id: 1229662
Other names: P. fici W106-1, Pestalotiopsis fici W106-1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PFICI_00248	PFICI_10940	W3XK94	W3WW34	Uncharacterized protein.	AMPKBI domain-containing protein.	0.426
PFICI_00248	PFICI_13137	W3XK94	W3WLA5	Uncharacterized protein.	AMPK1_CBM domain-containing protein.	0.426
PFICI_00419	PFICI_00743	W3XMR6	W3XLR2	Alpha-mann_mid domain-containing protein.	ATG11 domain-containing protein.	0.493
PFICI_00419	PFICI_06881	W3XMR6	W3X771	Alpha-mann_mid domain-containing protein.	Uncharacterized protein.	0.664
PFICI_00419	PFICI_08444	W3XMR6	W3X4C5	Alpha-mann_mid domain-containing protein.	Autophagy-related protein.	0.484
PFICI_00419	PFICI_09596	W3XMR6	W3X0W5	Alpha-mann_mid domain-containing protein.	Uncharacterized protein; Belongs to the peptidase M18 family.	0.693
PFICI_00419	PFICI_15392	W3XMR6	W3WG39	Alpha-mann_mid domain-containing protein.	Aspartyl aminopeptidase; Belongs to the peptidase M18 family.	0.678
PFICI_00543	PFICI_05328	W3XL57	W3XDF9	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.590
PFICI_00543	PFICI_07290	W3XL57	W3X851	Non-specific serine/threonine protein kinase.	Target of rapamycin complex subunit LST8.	0.947
PFICI_00543	PFICI_08091	W3XL57	W3X567	Non-specific serine/threonine protein kinase.	Rap-GAP domain-containing protein.	0.455
PFICI_00543	PFICI_11733	W3XL57	W3WU28	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.645
PFICI_00543	PFICI_13883	W3XL57	W3WLG8	Non-specific serine/threonine protein kinase.	WD_REPEATS_REGION domain-containing protein.	0.956
PFICI_00543	PFICI_14384	W3XL57	W3WKV1	Non-specific serine/threonine protein kinase.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.976
PFICI_00543	PFICI_14631	W3XL57	W3WID2	Non-specific serine/threonine protein kinase.	HRDC domain-containing protein.	0.572
PFICI_00614	PFICI_01866	W3XNG0	W3XPQ2	Autophagy_act_C domain-containing protein.	SWIM-type domain-containing protein.	0.569
PFICI_00614	PFICI_02906	W3XNG0	W3XI16	Autophagy_act_C domain-containing protein.	Autophagy-related protein 3.	0.664
PFICI_00614	PFICI_02998	W3XNG0	W3XFU6	Autophagy_act_C domain-containing protein.	Phosphatidylinositol 3-kinase VPS34.	0.655
PFICI_00614	PFICI_03495	W3XNG0	W3XHG1	Autophagy_act_C domain-containing protein.	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy.	0.662
PFICI_00614	PFICI_03529	W3XNG0	W3XHM8	Autophagy_act_C domain-containing protein.	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	0.655
PFICI_00614	PFICI_05023	W3XNG0	W3XCH5	Autophagy_act_C domain-containing protein.	Uncharacterized protein.	0.459